A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers.
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The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assemblyObstructing toxin pathways by targeted pore blockageGating transitions in bacterial ion channels measured at 3 microns resolutionPlasticity of listeriolysin O pores and its regulation by pH and unique histidine [corrected].Perfringolysin O structure and mechanism of pore formation as a paradigm for cholesterol-dependent cytolysinsStructural investigations of pneumolysin/lipid complexes.Phosphatase-dependent regulation of epithelial mitogen-activated protein kinase responses to toxin-induced membrane pores.Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines.Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin.Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis.Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tractDegradation products of the extracellular pathogen Streptococcus pneumoniae access the cytosol via its pore-forming toxin.Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from streptococcus pneumoniae in brain tissue.Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity.Neutralizing antibodies elicited by a novel detoxified pneumolysin derivative, PlyD1, provide protection against both pneumococcal infection and lung injuryListeriolysin O: a key protein of Listeria monocytogenes with multiple functions.Statin-conferred enhanced cellular resistance against bacterial pore-forming toxins in airway epithelial cellsDirect transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysinProtein arcs may form stable pores in lipid membranes.Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen.Epithelial cells are sensitive detectors of bacterial pore-forming toxins.Immunization with genetic toxoids of the Arcanobacterium pyogenes cholesterol-dependent cytolysin, pyolysin, protects mice against infection.Measuring kinetic drivers of pneumolysin pore structure.Incomplete pneumolysin oligomers form membrane pores.The Crystal Structure of Pneumolysin at 2.0 Å Resolution Reveals the Molecular Packing of the Pre-pore Complex.Probing pores with peptide plugs. Topology of membrane-inserted diphtheria toxin.CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis.Structure-guided antigen engineering yields pneumolysin mutants suitable for vaccination against pneumococcal disease.Structural analysis of the protein/lipid complexes associated with pore formation by the bacterial toxin pneumolysin.Chemical and photochemical modification of colicin E1 and gramicidin A in bilayer lipid membranes.The human-specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein.The mechanism of pneumolysin-induced cochlear hair cell death in the rat.Serum and mucosal antibody responses to pneumococcal protein antigens in children: relationships with carriage status.Interaction of Cholesterol with Perfringolysin O: What Have We Learned from Functional Analysis?Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema.Immunodominance in T cell responses elicited against different domains of detoxified pneumolysin PlyD1.Age-related differences in IL-1 signaling and capsule serotype affect persistence of Streptococcus pneumoniae colonization
P2860
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P2860
A conserved tryptophan in pneumolysin is a determinant of the characteristics of channels formed by pneumolysin in cells and planar lipid bilayers.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@en
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@nl
type
label
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@en
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@nl
prefLabel
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@en
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@nl
P2093
P2860
P356
P1433
P1476
A conserved tryptophan in pneu ...... lls and planar lipid bilayers.
@en
P2093
C A Pasternak
C L Bashford
C Pederzolli
P J Morgan
P W Andrew
Y E Korchev
P2860
P304
P356
10.1042/BJ3290571
P407
P478
329 ( Pt 3)
P577
1998-02-01T00:00:00Z