HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA.
about
Structural characterization of the highly conserved 98-base sequence at the 3' end of HCV RNA genome and the complementary sequence located at the 5' end of the replicative viral strandSelection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymeraseSecondary structure and hybridization accessibility of hepatitis C virus 3'-terminal sequences.Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in CultureSecondary Structure of the 3' Terminus of Hepatitis C Virus Minus-Strand RNAMathematical Modeling of Subgenomic Hepatitis C Virus Replication in Huh-7 CellsMechanism of Activation of -D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA PolymeraseIdentification of Determinants Involved in Initiation of Hepatitis C Virus RNA Synthesis by Using Intergenotypic Replicase ChimerasBiochemical characterization of a recombinant Japanese encephalitis virus RNA-dependent RNA polymeraseExpression of hepatitis C virus proteins in epithelial intestinal cells in vivoSignificance in Replication of the Terminal Nucleotides of the Flavivirus GenomeInhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected CellsThe Hepatitis C Virus NS5A Stimulates NS5B During In Vitro RNA Synthesis in a Template Specific MannerFurther Insights into the Roles of GTP and the C Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA SynthesisStructure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNATwo Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405Structural and functional analysis of the cis-acting elements required for plus-strand RNA synthesis of Bamboo mosaic virus.Identification of a structural element of the hepatitis C virus minus strand RNA involved in the initiation of RNA synthesisStructure-based design of hepatitis C virus inhibitors.Characterization of a nodavirus replicase revealed a de novo initiation mechanism of RNA synthesis and terminal nucleotidyltransferase activityAutophagy and microRNA dysregulation in liver diseases.An RNA aptamer containing two binding sites against the HCV minus-IRES domain I.Functional RNA structures throughout the Hepatitis C Virus genome.Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system.Three-dimensional structure of the 3'X-tail of hepatitis C virus RNA in monomeric and dimeric states.Positional effects and strand preference of RNA interference against hepatitis C virus target sequences.A cell-based model of HCV-negative-strand RNA replication utilizing a chimeric hepatitis C virus/reporter RNA template.Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.Flock house virus RNA polymerase initiates RNA synthesis de novo and possesses a terminal nucleotidyl transferase activity.Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance.Requirements for West Nile virus (-)- and (+)-strand subgenomic RNA synthesis in vitro by the viral RNA-dependent RNA polymerase expressed in Escherichia coli.Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.Promoter/origin structure of the complementary strand of hepatitis C virus genome.Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.Form confers function: Case of the 3'X region of the hepatitis C virus genomeA closed-handed affair: positive-strand RNA virus polymerases
P2860
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P2860
HCV RNA-dependent RNA polymerase replicates in vitro the 3' terminal region of the minus-strand viral RNA more efficiently than the 3' terminal region of the plus RNA.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@en
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@nl
type
label
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@en
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@nl
prefLabel
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@en
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@nl
P2093
P2860
P1433
P1476
HCV RNA-dependent RNA polymera ...... rminal region of the plus RNA.
@en
P2093
L Sarih-Cottin
M Castroviejo
S Reigadas
T Astier-Gin
P2860
P304
P356
10.1046/J.0014-2956.2001.02532.X
P407
P577
2001-11-01T00:00:00Z