Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives. - Wikidata - awgldk - TriplyDB

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

http://www.wikidata.org/entity/Q43042125

about

Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and Resistance Inhibitory Effect of 2'-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells Mutations conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro.General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues Hepatitis C Virus (HCV) NS5B Nonnucleoside Inhibitors Specifically Block Single-Stranded Viral RNA Synthesis Catalyzed by HCV Replication Complexes In Vitro Pyrophosphorolytic Excision of Nonobligate Chain Terminators by Hepatitis C Virus NS5B Polymerase Inhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells A Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus Polymerase Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines 1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase.High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.Current and emerging therapeutic approaches to hepatitis C infection.Challenges and successes in developing new therapies for hepatitis C.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.Antiviral therapy for hepatitis C virus: beyond the standard of care.Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research.Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase.Characterization of the inhibition of hepatitis C virus RNA replication by nonnucleosides.Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.Screening of hepatitis C NS5B polymerase inhibitors containing benzothiadiazine core: a steered molecular dynamics.Molecular modeling study on the drug resistance mechanism of NS5B polymerase to TMC647055.

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P2860

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

http://www.wikidata.org/entity/Q43042125

description

2003 nî lūn-bûn

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2003年の論文

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2003年学术文章

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2003年学术文章

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2003年学术文章

@zh-cn

2003年学术文章

@zh-hans

2003年学术文章

@zh-my

2003年学术文章

@zh-sg

2003年學術文章

@yue

2003年學術文章

@zh-hant

name

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@en

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@nl

type

label

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@en

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@nl

prefLabel

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@en

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives.

@nl

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P1433

Journal of Biological Chemistry

P1476

Arresting initiation of hepatitis C virus RNA synthesis using heterocyclic derivatives

@en

P2093

Baohua Gu

http://www.w3.org/2001/XMLSchema#string

C Cheng Kao

http://www.w3.org/2001/XMLSchema#string

Dashyant Dhanak

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Lester L Gutshall

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Michael G Darcy

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Richard R Gontarek

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Robert T Sarisky

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Tammy T Nguyen

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Victor K Johnston

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P2860

Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase.

De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5B) of hepatitis C virus

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

Template requirements for RNA synthesis by a recombinant hepatitis C virus RNA-dependent RNA polymerase

Terminal nucleotidyl transferase activity of recombinant Flaviviridae RNA-dependent RNA polymerases: implication for viral RNA synthesis.

Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides

Selection of 3'-template bases and initiating nucleotides by hepatitis C virus NS5B RNA-dependent RNA polymerase

Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA Polymerases

Efficient initiation of HCV RNA replication in cell culture

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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16602-16607

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scholarly article

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10.1074/JBC.M210891200

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19

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278

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2003-01-27T00:00:00Z

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