Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
about
Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylationThe crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerasesThe modeled structure of the RNA dependent RNA polymerase of GBV-C virus suggests a role for motif E in Flaviviridae RNA polymerases.Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceThe yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNAUsing the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionCommon and unique features of viral RNA-dependent polymerasesReplication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymeraseA novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.Selection of RNA aptamers that are specific and high-affinity ligands of the hepatitis C virus RNA-dependent RNA polymeraseMechanism of de novo initiation by the hepatitis C virus RNA-dependent RNA polymerase: role of divalent metals.Requirements for De Novo Initiation of RNA Synthesis by Recombinant Flaviviral RNA-Dependent RNA PolymerasesRecombinant viral RdRps can initiate RNA synthesis from circular templates.Hepatitis C Virus RNA Synthesis in a Cell-Free System Isolated from Replicon-Containing Hepatoma CellsHepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinaseA structural and primary sequence comparison of the viral RNA-dependent RNA polymerasesSpecific Inhibition of Bovine Viral Diarrhea Virus ReplicaseCrystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase EnzymeDe Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template ParametersMolecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase InhibitorGeneral Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide AnaloguesCrystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom ResolutionBinding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase InhibitorsStabilization of Poliovirus Polymerase by NTP Binding and Fingers–Thumb InteractionsDe Novo Initiation of RNA Synthesis by the Arterivirus RNA-Dependent RNA PolymeraseCell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted VariantSignificance in Replication of the Terminal Nucleotides of the Flavivirus GenomeStructure-function relationships among RNA-dependent RNA polymerasesA Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus PolymeraseResistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine InhibitorNontemplated Terminal Nucleotidyltransferase Activity of Double-Stranded RNA Bacteriophage 6 RNA-Dependent RNA Polymerase1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside InhibitorsHepatitis C Virus NS5B Polymerase Exhibits Distinct Nucleotide Requirements for Initiation and ElongationThe Hepatitis C Virus NS5A Stimulates NS5B During In Vitro RNA Synthesis in a Template Specific MannerSlow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C VirusStructural and Functional Analysis of Hepatitis C Virus Strain JFH1 PolymeraseNon-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibitionCrystal Structure of Poliovirus 3CD Protein: Virally Encoded Protease and Precursor to the RNA-Dependent RNA Polymerase
P2860
Q24303935-A10C2D17-D2CB-4BBF-B436-957B06943CB8Q24646382-D214B1CF-C86F-44E7-B139-1F2DAD5CF045Q24810541-FE56FECE-0572-4FC9-9122-C1798F4C35B6Q26783056-EB2DE1FD-D3A7-4DE8-9533-08D4680AE6D3Q26800446-40AC48F2-093A-48D7-B3D4-F68B97A011C6Q26801762-2DCA3C44-FA98-434E-A808-9D59E1BF2A65Q26991855-AE0378DB-7034-4E4C-8678-36C3AA84FA6BQ27001753-F8E30ADE-6EE6-442B-8B67-EED3B193335CQ27469483-89B04D9C-471A-400B-AF7A-0F76717D0F44Q27471517-1FB38C9A-435F-4A54-9067-DF9D9E68DDCEQ27472778-2F70EF05-16D6-4437-AD99-19FC29D6ACE9Q27472862-DFDC5BF1-5A45-4509-BE7C-FFA6EEACF4E4Q27472913-744EC965-4EB6-468E-9822-F7DA75C1392CQ27472914-673CAB1E-5171-45AB-9338-115799B2133BQ27472979-E84D8CC9-3443-4822-92E4-7C5E758BC1C6Q27473087-39382611-4304-45C9-9A22-211142EC12BEQ27473152-E5A19A2E-5F9D-4C0A-AF3C-C5B3D6CC7BA6Q27473424-62D23ED3-1755-429A-9FD7-F2A6AFB51C4DQ27477452-4E0E3352-78A4-4FBF-8938-26A7652DCBA1Q27477662-454E7726-4823-4361-9951-98B64A54297DQ27477711-B5EE8484-E2AF-4F88-96DD-DFA688245ED7Q27477757-535115C4-85CC-434F-B6AF-F7271410FD95Q27477760-86C355D6-F371-43C8-9831-79EAD4396B1DQ27480349-B3645440-69B5-43A3-8954-8FFB33C92CA6Q27480926-6F2A4909-8FA7-4FDB-9AD2-36A8B1FBD5AFQ27480973-20E5126F-52BE-4A3B-A771-02467F624109Q27481017-13B43F21-704A-40E9-8EEB-D42E90441361Q27485033-5634C0B7-0D90-45CA-9F3E-E3A9610E1FDDQ27485661-952EF0C8-AD1E-43B2-84FB-BE41892C571DQ27486391-B43DD396-8F1B-44C6-A4E2-22D0242FB7D3Q27486419-8C5D6EA0-CE19-46A5-9F51-694DE7938E7CQ27486873-6968DDB5-3A78-45D7-A92E-C719DD3BFDD7Q27486918-23BD3B95-5735-4065-AC01-E070E50B8253Q27487390-C228ADB6-FB9C-4582-B47C-DAC2834CF3BBQ27488267-6F6BF28A-6E48-4AD6-A6B6-CCEC69E47E87Q27488841-ADCBBBD4-4CFA-4440-89CE-C3B6B8016A6DQ27488887-34BC334A-6F74-4128-9899-54740EE9BEDFQ27490320-72BB1747-706A-4830-947F-B29EF9F861F8Q27640261-F2E0AD32-32D2-41E4-B9B5-D4B052FDC663Q27643650-0A2BBC26-8B2C-4438-9D31-A8D13D8E1786
P2860
Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
description
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article scientifique (publié 2002-04)
@fr
articolo scientifico (pubblicato il 2002-04)
@it
artigo científico (publicado na 2002-04)
@pt
artículu científicu espublizáu en 2002
@ast
im April 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: April 2002)
@en
vedecký článok (publikovaný 2002-04)
@sk
videnskabelig artikel (udgivet 2002-04)
@da
name
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@ast
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@en
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@nl
type
label
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@ast
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@en
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@nl
prefLabel
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@ast
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@en
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@nl
P2860
P50
P3181
P1433
P1476
Structural Analysis of the Hep ...... n Complex with Ribonucleotides
@en
P2093
Licia Tomei
P2860
P304
P3181
P356
10.1128/JVI.76.7.3482-3492.2002
P577
2002-04-01T00:00:00Z