Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
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Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryThe cellular and physiological functions of the Lowe syndrome protein OCRL1Protein trafficking defects in inherited kidney diseasesDiscovery of CLC transport proteins: cloning, structure, function and pathophysiologyDifferentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biologyA mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule.The Concise Guide to PHARMACOLOGY 2013/14: ion channelsExpression and localization of CLC chloride transport proteins in the avian retina.Hereditary causes of kidney stones and chronic kidney diseaseDent's disease.Physiology and pathophysiology of ClC-K/barttin channels.Exploring emergent properties in cellular homeostasis using OnGuard to model K+ and other ion transport in guard cellsChloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3).Role of pH in a nitric oxide-dependent increase in cytosolic Cl- in retinal amacrine cells.A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells.Requirement for chloride channel function during the hepatitis C virus life cycle.On the mechanism of gating charge movement of ClC-5, a human Cl(-)/H(+) antiporterSynergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger.Host pathways important for Coxiella burnetii infection revealed by genome-wide RNA interference screening.Salt, chloride, bleach, and innate host defense.Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients.A patient with nephrotic-range proteinuria and focal global glomerulosclerosis.A single point mutation reveals gating of the human ClC-5 Cl-/H+ antiporter.Dent's disease: clinical features and molecular basis.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Neurotransmitter corelease: mechanism and physiological role.ClC-5 mutations associated with Dent's disease: a major role of the dimer interface.Vesicular and plasma membrane transporters for neurotransmitters.The CLC-5 2Cl(-)/H(+) exchange transporter in endosomal function and Dent's disease.Cell biology and physiology of CLC chloride channels and transporters.Ca2+-activated Cl- channels.Chloride transport.Osteopetrosis: genetics, treatment and new insights into osteoclast function.Uriniferous tubule: structural and functional organization.Functions of volume-sensitive and calcium-activated chloride channels.Chloride transporters and receptor-mediated endocytosis in the renal proximal tubule.Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1.A tale of two CLCs: biophysical insights toward understanding ClC-5 and ClC-7 function in endosomes and lysosomes.Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.A pure chloride channel mutant of CLC-5 causes Dent's disease via insufficient V-ATPase activation.
P2860
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P2860
Endosomal chloride-proton exchange rather than chloride conductance is crucial for renal endocytosis.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@en
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@nl
type
label
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@en
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@nl
prefLabel
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@en
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@nl
P2093
P2860
P356
P1433
P1476
Endosomal chloride-proton exch ...... crucial for renal endocytosis.
@en
P2093
Gaia Novarino
Gesa Rickheit
Stefanie Weinert
P2860
P304
P356
10.1126/SCIENCE.1188070
P407
P577
2010-04-29T00:00:00Z