Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression. - Wikidata - awgldk - TriplyDB

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.

Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.

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Biomedical and clinical promises of human pluripotent stem cells for neurological disorders Quo vadis motor neuron disease?The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency Neurodegenerative diseases in a dish: the promise of iPSC technology in disease modeling and therapeutic discovery Induced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous System Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism A synergetic screening approach with companion effector for combination therapy: application to retinoblastoma Efficient and versatile CRISPR engineering of human neurons in culture to model neurological disorders Human pluripotent stem cells on artificial microenvironments: a high content perspective Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications.Stem cell models of Alzheimer's disease: progress and challenges.Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord.Differential sensitivity to JAK inhibitory drugs by isogenic human erythroblasts and hematopoietic progenitors generated from patient-specific induced pluripotent stem cells Induced Pluripotent Stem Cells: Global Research Trends.A virtual screen identified C96 as a novel inhibitor of phosphatidylinositol 3-kinase that displays potent preclinical activity against multiple myeloma in vitro and in vivo Feeder-free derivation of neural crest progenitor cells from human pluripotent stem cells.Pluripotent stem cells: the last 10 years.Stem cells and small molecule screening: haploid embryonic stem cells as a new tool.A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells.Compounds with species and cell type specific toxicity identified in a 2000 compound drug screen of neural stem cells and rat mixed cortical neurons Modeling human neurological disorders with induced pluripotent stem cells.Small molecule screening in human induced pluripotent stem cell-derived terminal cell types.Epigenetic therapy for Friedreich ataxia Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media Advances in reprogramming-based study of neurologic disorders Probing disorders of the nervous system using reprogramming approaches.Niemann-Pick Disease Type C: Induced Pluripotent Stem Cell-Derived Neuronal Cells for Modeling Neural Disease and Evaluating Drug Efficacy.Phenotypic screens as a renewed approach for drug discovery.Induced Pluripotent Stem Cells for Disease Modeling and Evaluation of Therapeutics for Niemann-Pick Disease Type A RBM24 promotes U1 snRNP recognition of the mutated 5' splice site in the IKBKAP gene of familial dysautonomia.Feeder-free Derivation of Melanocytes from Human Pluripotent Stem Cells High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.Treatment Paradigms for Retinal and Macular Diseases Using 3-D Retina Cultures Derived From Human Reporter Pluripotent Stem Cell Lines.A novel high throughput 1536-well Notch1 γ -secretase AlphaLISA assay A robust method to derive functional neural crest cells from human pluripotent stem cells.Derivation of Diverse Hormone-Releasing Pituitary Cells from Human Pluripotent Stem Cells.PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front

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Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression.

http://www.wikidata.org/entity/Q43092271

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Nature Biotechnology

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Large-scale screening using fa ...... that rescue IKBKAP expression.

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Becky Liu

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Bhavneet Bhinder

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Bipasha Mukherjee-Clavin

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Christina N Ramirez

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Constantin Radu

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Gabsang Lee

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Hakim Djaballah

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Hyesoo Kim

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In Young Choi

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Nadja Zeltner

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P2860

Modelling schizophrenia using human induced pluripotent stem cells.

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

Induced pluripotent stem cells from a spinal muscular atrophy patient

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells

Modelling the long QT syndrome with induced pluripotent stem cells

Patient-specific induced pluripotent stem-cell models for long-QT syndrome

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

A comparative genomics approach to identifying the plasticity transcriptome.

High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells

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1244-1248

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10.1038/NBT.2435

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