Epigenetic therapy for Friedreich ataxia - Wikidata - awgldk - TriplyDB

Epigenetic therapy for Friedreich ataxia

Epigenetic therapy for Friedreich ataxia

http://www.wikidata.org/entity/Q35180607

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Epigenetics and Triplet-Repeat Neurological Diseases Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders The promise and perils of HDAC inhibitors in neurodegeneration Activating frataxin expression by repeat-targeted nucleic acids Lymphoblast Oxidative Stress Genes as Potential Biomarkers of Disease Severity and Drug Effect in Friedreich's Ataxia Pharmacological treatments for Friedreich ataxia.Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich's Ataxia.FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia.Frataxin levels in peripheral tissue in Friedreich ataxia.Friedreich's ataxia--a case of aberrant transcription termination?Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets.Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia.Statistical Enrichment of Epigenetic States Around Triplet Repeats that Can Undergo Expansions.Reversal of epigenetic promoter silencing in Friedreich ataxia by a class I histone deacetylase inhibitor.Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells.E3 Ligase RNF126 Directly Ubiquitinates Frataxin, Promoting Its Degradation: Identification of a Potential Therapeutic Target for Friedreich Ataxia.Stem cells - biological update and cell therapy progress.Pluripotent stem cells in disease modelling and drug discovery.Friedreich Ataxia: current status and future prospects.Current concepts in the treatment of hereditary ataxias.Modeling simple repeat expansion diseases with iPSC technology.hiPSC Disease Modeling of Rare Hereditary Cerebellar Ataxias.Translating HDAC inhibitors in Friedreich's ataxia.Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease.Characterization of human mitochondrial ferritin promoter: identification of transcription factors and evidences of epigenetic control.Pharmacological therapeutics in Friedreich ataxia: the present state.Peptide SS-31 upregulates frataxin expression and improves the quality of mitochondria: implications in the treatment of Friedreich ataxia.New Reasons to Pursue the Therapeutic Potential of Synthetic Nucleic Acids for Neurological Diseases.A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia Friedreich ataxia-induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitor.Overexpression of Drosophila frataxin triggers cell death in an iron-dependent manner.Synthetic transcription elongation factors license transcription across repressive chromatin.Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat.Long-term treatment with thiamine as possible medical therapy for Friedreich ataxia.Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy.Emerging therapeutics for the treatment of Friedreich’s ataxia

P2860

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P2860

Epigenetic therapy for Friedreich ataxia

http://www.wikidata.org/entity/Q35180607

description

2014 nî lūn-bûn

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2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

@wuu

name

Epigenetic therapy for Friedreich ataxia

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Epigenetic therapy for Friedreich ataxia

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type

label

Epigenetic therapy for Friedreich ataxia

@ast

Epigenetic therapy for Friedreich ataxia

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prefLabel

Epigenetic therapy for Friedreich ataxia

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Epigenetic therapy for Friedreich ataxia

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P1433

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P1433

Annals of Neurology

P1476

Epigenetic therapy for Friedreich ataxia

@en

P2093

Anton Maximov

http://www.w3.org/2001/XMLSchema#string

Antonio Piga

http://www.w3.org/2001/XMLSchema#string

David Jacoby

http://www.w3.org/2001/XMLSchema#string

Elisabetta Soragni

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Erica Campau

http://www.w3.org/2001/XMLSchema#string

James R Rusche

http://www.w3.org/2001/XMLSchema#string

Jeanne F Loring

http://www.w3.org/2001/XMLSchema#string

Jintang Du

http://www.w3.org/2001/XMLSchema#string

Joseph C Madara

http://www.w3.org/2001/XMLSchema#string

Kristopher Nazor

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P2860

Transcription promotes contraction of CAG repeat tracts in human cells

Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.

The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure

HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model

Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo

Development of frataxin gene expression measures for the evaluation of experimental treatments in Friedreich's ataxia

Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

P304

489-508

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scholarly article

P356

10.1002/ANA.24260

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4

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P478

76

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P50

Joel M. Gottesfeld

Pablo Peñalver

P577

2014-09-16T00:00:00Z

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265091326

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25159818

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P932

4361037

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