1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.
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The role of IDO in brain tumor immunotherapyIDO2 in Immunomodulation and Autoimmune DiseaseTrial watch: IDO inhibitors in cancer therapyMolecular evolution and characterization of fungal indoleamine 2,3-dioxygenases.Inflammation-associated depression: from serotonin to kynurenineIDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation.IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis.Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancerInfluence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase.Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4.Gene silencing of indoleamine 2,3-dioxygenase 2 in melanoma cells induces apoptosis through the suppression of NAD+ and inhibits in vivo tumor growth.The SOCS3-independent expression of IDO2 supports the homeostatic generation of T regulatory cells by human dendritic cells.Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 - 2012).Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease.Low efficiency IDO2 enzymes are conserved in lower vertebrates, whereas higher efficiency IDO1 enzymes are dispensable.Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes.Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation.Tryptophan Catabolism and Cancer Immunotherapy Targeting IDO Mediated Immune Suppression.High l-Trp affinity of indoleamine 2,3-dioxygenase 1 is attributed to two residues located in the distal heme pocket.Endothelial indoleamine 2,3-dioxygenase-1 regulates the placental vascular tone and is deficient in intrauterine growth restriction and pre-eclampsia.Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human CellsLipopolysaccharide shock reveals the immune function of indoleamine 2,3-dioxygenase 2 through the regulation of IL-6/stat3 signalling
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P2860
1-L-methyltryptophan is a more effective inhibitor of vertebrate IDO2 enzymes than 1-D-methyltryptophan.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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name
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@en
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@nl
type
label
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@en
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@nl
prefLabel
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@en
1-L-methyltryptophan is a more ...... mes than 1-D-methyltryptophan.
@nl
P2093
P1476
1-L-methyltryptophan is a more ...... ymes than 1-D-methyltryptophan
@en
P2093
Christopher J D Austin
Hajime J Yuasa
Nicholas H Hunt
P356
10.1016/J.CBPB.2010.04.006
P50
P577
2010-04-23T00:00:00Z