Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
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Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated mannerTargeting Cell Survival Proteins for Cancer Cell DeathAnti-apoptotic BCL-2 family proteins in acute neural injuryLa FAM fatale: USP9X in development and diseaseDiscernment of possible mechanisms of hepatotoxicity via biological processes over-represented by co-expressed genesIn vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L.Effect of nitric oxide on mitochondrial activity of human synovial cells.Mcl-1 ubiquitination: unique regulation of an essential survival protein.Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration modelsThe essential role of evasion from cell death in cancer.MCL1 increases primitive thymocyte viability in female mice and promotes thymic expansion into adulthoodmiR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury.Myeloid cell leukemia 1 (Mcl(-1)) protects against 1-methyl-4-phenylpyridinium ion (MPP+) induced apoptosis in Parkinson's disease.Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration.Delving deeper: MCL-1's contributions to normal and cancer biology.Functional expression of SCL/TAL1 interrupting locus (Stil) protects retinal dopaminergic cells from neurotoxin-induced degeneration.Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neuronsAttacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersBcl-xL Is Essential for the Survival and Function of Differentiated Neurons in the Cortex That Control Complex Behaviors.Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction.Growth hormone and melatonin prevent age-related alteration in apoptosis processes in the dentate gyrus of male ratsTonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastomaIdentification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.Regulation of the autophagic bcl-2/beclin 1 interaction.The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.CREB: a multifaceted regulator of neuronal plasticity and protection.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesCentral roles of apoptotic proteins in mitochondrial function.Programming cancer cells for high expression levels of Mcl1.Small molecule Mcl-1 inhibitors for the treatment of cancer.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Early development of the neural plate: new roles for apoptosis and for one of its main effectors caspase-3.Cell death in development: Signaling pathways and core mechanisms.Cdk5-Mcl-1 axis promotes mitochondrial dysfunction and neurodegeneration in Alzheimer's disease model.Alcohol-Mediated Missplicing of Mcl-1 Pre-mRNA is Involved in Neurotoxicity.Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1.
P2860
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P2860
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@en
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@nl
type
label
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@en
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@nl
prefLabel
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@en
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@nl
P2093
P2860
P1476
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
@en
P2093
Alexander E MacKenzie
Arezu Jahani-Asl
David S Park
Eric C C Cheung
J Nicole Le Grand
Jacqueline L Vanderluit
Joseph T Opferman
Melissa A Kelly
Nicole Arbour
Ruth S Slack
P2860
P304
P356
10.1523/JNEUROSCI.4940-07.2008
P407
P577
2008-06-01T00:00:00Z