Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme.
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Single-Atom Imino Substitutions at A9 and A10 Reveal Distinct Effects on the Fold and Function of the Hairpin Ribozyme Catalytic CoreSmall self-cleaving ribozymesDo the hairpin and VS ribozymes share a common catalytic mechanism based on general acid-base catalysis? A critical assessment of available experimental data.Evidence for the role of active site residues in the hairpin ribozyme from molecular simulations along the reaction path.The pH dependence of hairpin ribozyme catalysis reflects ionization of an active site adenineBase ionization and ligand binding: how small ribozymes and riboswitches gain a foothold in a protein world.Constant pH Molecular Dynamics Simulations of Nucleic Acids in Explicit Solvent.Modified 6-aza uridines: highly emissive pH-sensitive fluorescent nucleosides.A DNAzyme requiring two different metal ions at two distinct sitespH-dependent dynamics of complex RNA macromoleculesTowards Accurate Prediction of Protonation Equilibrium of Nucleic Acids.The DNA and RNA sugar-phosphate backbone emerges as the key player. An overview of quantum-chemical, structural biology and simulation studies.Excited-state proton transfer and phototautomerism in nucleobase and nucleoside analogs: a mini-review.8-Azapurines as isosteric purine fluorescent probes for nucleic acid and enzymatic research.Direct observation of multiple tautomers of oxythiamine and their recognition by the thiamine pyrophosphate riboswitch.Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.Charged nucleobases and their potential for RNA catalysis.An active-site guanine participates in glmS ribozyme catalysis in its protonated stateExperimental approaches for measuring pKa's in RNA and DNA.QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms.Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme.Protonation states of the key active site residues and structural dynamics of the glmS riboswitch as revealed by molecular dynamics.General acid-base catalysis mediated by nucleobases in the hairpin ribozyme.Identification of the catalytic Mg²⁺ ion in the hepatitis delta virus ribozyme.Pressure modulates the self-cleavage step of the hairpin ribozyme.Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation.glmS Riboswitch binding to the glucosamine-6-phosphate α-anomer shifts the pKa toward neutrality.Spectroscopic probes of RNA structure and dynamics.Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations.Enzymatic synthesis of highly fluorescent 8-azapurine ribosides using a purine nucleoside phosphorylase reverse reaction: variable ribosylation sites.
P2860
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P2860
Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@en
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@nl
type
label
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@en
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@nl
prefLabel
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@en
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@nl
P2093
P2860
P356
P1476
Direct measurement of the ioni ...... anine in the hairpin ribozyme.
@en
P2093
Joseph W Cottrell
Lincoln G Scott
Martha J Fedor
P2860
P2888
P304
P356
10.1038/NCHEMBIO.156
P577
2009-03-29T00:00:00Z