The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets.
about
Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infectionPI3K p110δ is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTβR mRNA levelsCyclosporin a inhibits rotavirus replication and restores interferon-beta signaling pathway in vitro and in vivoDeficiency of p110δ isoform of the phosphoinositide 3 kinase leads to enhanced resistance to Leishmania donovaniMHC class II restricted innate-like double negative T cells contribute to optimal primary and secondary immunity to Leishmania majorLipid signaling in T-cell development and functionPI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.Deficiency of Leishmania phosphoglycans influences the magnitude but does not affect the quality of secondary (memory) anti-Leishmania immunityPhosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial InfectionsSecreted virulence factors and immune evasion in visceral leishmaniasis.Protective immunity and vaccination against cutaneous leishmaniasis.The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.PI3K signaling in Leishmania infections.Deficiency of prolactin-inducible protein leads to impaired Th1 immune response and susceptibility to Leishmania major in mice.Pharmacological inhibition of p110δ subunit of PI3K confers protection against experimental leishmaniasis.Hepatic stellate cells regulate liver immunity to visceral leishmaniasis through P110δ-dependent induction and expansion of regulatory T cells in mice.PI3Kδ Inhibition Enhances the Antitumor Fitness of Adoptively Transferred CD8+ T Cells
P2860
Q27322520-73DC211D-204C-4863-9991-562AE7F40DCCQ28512141-869128D6-20FD-4B69-8187-BE7A3E3C9172Q28535489-39C030F7-8C3D-482E-8CB4-93328B9F1743Q28539842-1E09AF8E-3BC2-45D2-91D4-DBD3D8DA63ADQ34215441-6C6E2618-ABC9-4794-BA20-8F555852CFEDQ34241131-FD2EAED4-E51A-4929-A022-02ED01451DDCQ34342465-654D9798-82F2-45C9-935E-F10371656449Q34641201-CD3023F2-6639-438F-BF9E-677227B97F5EQ34776215-D99C86ED-FE51-40F8-8544-99254DCA7F15Q36601779-9E2D16D1-02A7-45F7-B13E-BEBC802C7B89Q37996396-23CB10D5-5DB9-4454-BCAF-0D6A05A7BDC9Q38015852-958B9A15-446C-4B36-931E-E7D5413F5109Q38035848-36E0F919-D9B0-4A46-8D5C-811FE3ADE798Q38953117-1FDCFAF9-12F1-426C-A880-1213071BF3ADQ39175542-388FA0AB-1908-4FA8-9C61-22075A7774FAQ40401733-D926FEA9-B296-493E-95E4-4F3FB143FDAEQ41043666-1AA74083-CC27-4997-B0E8-B168DEE0BFDEQ42369747-ABD0A679-9A9B-415D-8D3B-1BDD27D66CBD
P2860
The p110 delta isoform of phosphatidylinositol 3-kinase controls the quality of secondary anti-Leishmania immunity by regulating expansion and effector function of memory T cell subsets.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@en
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@nl
type
label
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@en
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@nl
prefLabel
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@en
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@nl
P356
P1476
The p110 delta isoform of phos ...... tion of memory T cell subsets.
@en
P2093
Jude E Uzonna
P304
P356
10.4049/JIMMUNOL.0903177
P407
P577
2010-02-12T00:00:00Z