Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic.
about
Protein kinase inhibitors against malignant lymphomaInhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.SYK as a New Therapeutic Target in B-Cell Precursor Acute Lymphoblastic Leukemia.Nanopharmacology in translational hematology and oncologyCD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells.Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Syk activation of phosphatidylinositol 3-kinase/Akt prevents HtrA2-dependent loss of X-linked inhibitor of apoptosis protein (XIAP) to promote survival of Epstein-Barr virus+ (EBV+) B cell lymphomas.Liposomal Nanoparticles of a Spleen Tyrosine Kinase P-Site Inhibitor Amplify the Potency of Low Dose Total Body Irradiation Against Aggressive B-Precursor Leukemia and Yield Superior Survival Outcomes in MiceThe SYK tyrosine kinase: a crucial player in diverse biological functions.Nanoscale liposomal formulation of a SYK P-site inhibitor against B-precursor leukemiaTargeting Mantle Cell Lymphoma with Anti-SYK Nanoparticles.Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas.The Syk kinase as a therapeutic target in leukemia and lymphoma.Tyrosine kinase inhibitors as potential drugs for B-cell lymphoid malignancies and autoimmune disorders.Pediatric relapsed or refractory leukemia: new pharmacotherapeutic developments and future directions.Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition.Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network.
P2860
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P2860
Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic.
description
2010 nî lūn-bûn
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2010年の論文
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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2010年学术文章
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name
Targeting SYK kinase-dependent ...... inhibitory pentapeptide mimic.
@en
Targeting SYK kinase-dependent ...... acute lymphoblastic leukaemia
@nl
type
label
Targeting SYK kinase-dependent ...... inhibitory pentapeptide mimic.
@en
Targeting SYK kinase-dependent ...... acute lymphoblastic leukaemia
@nl
prefLabel
Targeting SYK kinase-dependent ...... inhibitory pentapeptide mimic.
@en
Targeting SYK kinase-dependent ...... acute lymphoblastic leukaemia
@nl
P2093
P1476
Targeting SYK kinase-dependent ...... inhibitory pentapeptide mimic.
@en
P2093
Chun-Lin Chen
Sanjive Qazi
Shyi-Tai Jan
P304
P356
10.1111/J.1365-2141.2010.08106.X
P407
P577
2010-02-11T00:00:00Z