about
Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of IkarosGerminal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activationThe kinase Syk as an adaptor controlling sustained calcium signalling and B-cell developmentMolecular mechanism of the Syk activation switchSyk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor3D structure of Syk kinase determined by single-particle electron microscopySYK expression in human breast cancerSyk-mediated translocation of PI3Kdelta to the leading edge controls lamellipodium formation and migration of leukocytesThe Syk kinase SmTK4 of Schistosoma mansoni is involved in the regulation of spermatogenesis and oogenesisKos1, a nonreceptor tyrosine kinase that suppresses Ras signalingTyrosine phosphorylation within the intrinsically disordered cytosolic domains of the B-cell receptor: an NMR-based structural analysisEnhancement of B-cell receptor signaling by a point mutation of adaptor protein 3BP2 identified in human inherited disease cherubism.Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFATAdaptor protein 3BP2 is a potential ligand of Src homology 2 and 3 domains of Lyn protein-tyrosine kinase.BAY 61-3606, CDKi, and sodium butyrate treatments alter gene expression in human vestibular schwannomas and cause cell death in vitro.Conformational rearrangements upon Syk auto-phosphorylation.Coordination of Fc receptor signaling regulates cellular commitment to phagocytosis.Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets.Proteomic and genetic approaches identify Syk as an AML target.Co-expression network analysis identifies Spleen Tyrosine Kinase (SYK) as a candidate oncogenic driver in a subset of small-cell lung cancerSTAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress.G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.Tyrosines in the carboxyl terminus regulate Syk kinase activity and functionSpleen tyrosine kinase inhibitors for rheumatoid arthritis: where are we now?Dectin-1-mediated signaling leads to characteristic gene expressions and cytokine secretion via spleen tyrosine kinase (Syk) in rat mast cells.Distinct mechanisms of a phosphotyrosyl peptide binding to two SH2 domainsActivation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK.Intracellular signal pathways: potential for therapies.Progress towards the development of SH2 domain inhibitors.Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.Bi-directional calcium signaling between adjacent leukocytes and trophoblast-like cells.Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrapComprehensive gene expression profiling reveals synergistic functional networks in cerebral vessels after hypertension or hypercholesterolemia.Inhibition of Syk protein tyrosine kinase induces apoptosis and blocks proliferation in T-cell non-Hodgkin's lymphoma cell lines.Regulation and function of syk tyrosine kinase in mast cell signaling and beyond.A PKC-SHP1 signaling axis desensitizes Fcγ receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcγR mediated phagocytosis.Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylationCorrelation of disease activity in proliferative glomerulonephritis with glomerular spleen tyrosine kinase expression.
P2860
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P2860
description
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im August 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/08/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/08/01)
@nl
наукова стаття, опублікована в серпні 2001
@uk
مقالة علمية (نشرت في أغسطس 2001)
@ar
name
Structure and function of Syk protein-tyrosine kinase
@ast
Structure and function of Syk protein-tyrosine kinase
@en
Structure and function of Syk protein-tyrosine kinase
@nl
type
label
Structure and function of Syk protein-tyrosine kinase
@ast
Structure and function of Syk protein-tyrosine kinase
@en
Structure and function of Syk protein-tyrosine kinase
@nl
prefLabel
Structure and function of Syk protein-tyrosine kinase
@ast
Structure and function of Syk protein-tyrosine kinase
@en
Structure and function of Syk protein-tyrosine kinase
@nl
P2093
P1476
Structure and function of Syk protein-tyrosine kinase
@en
P2093
P304
P356
10.1093/OXFORDJOURNALS.JBCHEM.A002970
P577
2001-08-01T00:00:00Z