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A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepaciaUniversal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids.Catalytic asymmetric synthesis of a potent thiomarinol antibiotic.Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: a comprehensive survey.A mild and general solid-phase method for the synthesis of chiral polyamines. Solution studies on the cleavage of borane-amine intermediates from the reduction of secondary amides.Combinatorial approach to selective multivalent ion pairing in mixed aqueous-organic media using bead-supported libraries of unnatural polyamines.Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation.Synthesis and high performance liquid chromatography/electrospray mass spectrometry single-bead decoding of split-pool structural libraries of polyamines supported on polystyrene and polystyrene/ethylene glycol resins.Wanted: new multicomponent reactions for generating libraries of polycyclic natural products.Screening of a combinatorial library of synthetic polyamines displaying selectivity in multiple ion-pairing interactions with model polyanionic compounds in aqueous organic solutions.Optimization of three- and four-component reactions for polysubstituted piperidines: application to the synthesis and preliminary biological screening of a prototype library.Diversity-oriented synthesis and preliminary biological screening of highly substituted five-membered lactones and lactams originating from an allyboration of aldehydes and imines.Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.Design, synthesis, and screening of a library of peptidyl bis(boroxoles) as oligosaccharide receptors in water: identification of a receptor for the tumor marker TF-antigen disaccharide.Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.Catalytic enantioselective diversity-oriented synthesis of a small library of polyhydroxylated pyrans inspired from thiomarinol antibiotics.Ring Structure and Aromatic Substituent Effects on the pK a of the Benzoxaborole Pharmacophore.Concise synthesis and antimalarial activity of all four mefloquine stereoisomers using a highly enantioselective catalytic borylative alkene isomerization.Boronic acid catalysis for mild and selective [3+2] dipolar cycloadditions to unsaturated carboxylic acids.Multistep phase-switch synthesis by using liquid-liquid partitioning of boronic acids: productive tags with an expanded repertoire of compatible reactions.Total synthesis of (+)-chinensiolide B via tandem allylboration/lactonization.Dramatic rate enhancement with preservation of stereospecificity in the first metal-catalyzed additions of allylboronates.3-Boronoacrolein as an exceptional heterodiene in the highly enantio- and diastereoselective Cr(III)-catalyzed three-component [4+2]/allylboration.A three-component reaction for diversity-oriented synthesis of polysubstituted piperidines: solution and solid-phase optimization of the first tandem aza[4+2]/allylboration.Effect of additives on the stereochemical integrity and reactivity of alpha-alkoxycarbonyl alkenylcopper intermediates. Optimal conditions for the synthesis of isomerically pure tetrasubstituted alkenes.Scandium-catalyzed allylboration of aldehydes as a practical method for highly diastereo- and enantioselective construction of homoallylic alcohols.Recent advances in the activation of boron and silicon reagents for stereocontrolled allylation reactions.Lewis acids catalyze the addition of allylboronates to aldehydes by electrophilic activation of the dioxaborolane in a closed transition structure.Synthesis of the non-peptidic snail toxin 6-bromo-2-mercaptotryptamine dimer (BrMT)(2), its lower and higher thio homologs and their ability to modulate potassium ion channels.Design of a nonreductive method for chemoselective cleavage of hydrazines in the presence of unsaturations: application to a stereoconvergent three-component synthesis of (-)-methyl palustramate.Alpha-hydroxyalkyl heterocycles via chiral allylic boronates: Pd-catalyzed borylation leading to a formal enantioselective isomerization of allylic ether and amine.Rationally improved chiral Brønsted acid for catalytic enantioselective allylboration of aldehydes with an expanded reagent scope.Practical and efficient multigram preparation of a camphor-derived diol for the enantioselective Lewis acid catalyzed allylboration of aldehydes.Catalytic enantioselective allyl- and crotylboration of aldehydes using chiral diol x SnCl4 complexes. optimization, substrate scope and mechanistic investigations.Brønsted acid-catalyzed allylboration: short and stereodivergent synthesis of all four eupomatilone diastereomers with crystallographic assignments.Synthesis and preliminary antibacterial evaluation of simplified thiomarinol analogs.Investigation of nonspecific effects of different dyes in the screening of labeled carbohydrates against immobilized proteins.Catalytic enantioselective three-component hetero-[4+2] cycloaddition/allylboration approach to alpha-hydroxyalkyl pyrans: scope, limitations, and mechanistic proposal.Catalytic enantioselective and catalyst-controlled diastereofacial-selective additions of allyl- and crotylboronates to aldehydes using chiral Brønsted acids.
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Dennis G Hall
@ast
Dennis G Hall
@en
Dennis G Hall
@es
Dennis G Hall
@nl
Dennis G Hall
@sl
type
label
Dennis G Hall
@ast
Dennis G Hall
@en
Dennis G Hall
@es
Dennis G Hall
@nl
Dennis G Hall
@sl
prefLabel
Dennis G Hall
@ast
Dennis G Hall
@en
Dennis G Hall
@es
Dennis G Hall
@nl
Dennis G Hall
@sl
P1053
E-6865-2016
P106
P21
P31
P3829
P496
0000-0001-8555-6400
P569
2000-01-01T00:00:00Z