The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.
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Functional features cause misfolding of the ALS-provoking enzyme SOD1Amino Acid Insertion Reveals a Necessary Three-Helical Intermediate in the Folding Pathway of the Colicin E7 Immunity Protein Im7Following evolutionary paths to protein-protein interactions with high affinity and selectivityCold denaturation of a protein dimer monitored at atomic resolutionCutting off functional loops from homodimeric enzyme superoxide dismutase 1 (SOD1) leaves monomeric β-barrels.Using hydroxyl radical footprinting to explore the free energy landscape of protein folding.Desolvation and development of specific hydrophobic core packing during Im7 folding.Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation.Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein.Dynameomics: a comprehensive database of protein dynamics.Dynamic regulation on energy landscape evolution of single-molecule protein by conformational fluctuation.Frustration in biomoleculesMalleability of folding intermediates in the homeodomain superfamilyNative contact density and nonnative hydrophobic effects in the folding of bacterial immunity proteins.Strand swapping regulates the iron-sulfur cluster in the diabetes drug target mitoNEETNonnative interactions regulate folding and switching of myristoylated protein.Substrate protein folds while it is bound to the ATP-independent chaperone SpyVisualizing chaperone-assisted protein folding.A molecular mechanism of chaperone-client recognition.Nuclease colicins and their immunity proteins.Understanding how small helical proteins fold: conformational dynamics of Im proteins relevant to their folding landscapes.Mechanistic studies of the biogenesis and folding of outer membrane proteins in vitro and in vivo: what have we learned to date?Folding while bound to chaperones.Single-molecule studies of the Im7 folding landscape.Forces Driving Chaperone ActionDissecting key residues in folding and stability of the bacterial immunity protein 7Reassessing the folding of the KIX domain: evidence for a two-state mechanismConformational properties of the unfolded state of Im7 in nondenaturing conditionsConformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7.Molecular recognition and packing frustration in a helical protein.Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins.Misfolding of luciferase at the single-molecule level.
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P2860
The mechanism of folding of Im7 reveals competition between functional and kinetic evolutionary constraints.
description
2009 nî lūn-bûn
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2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
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2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
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@yue
2009年學術文章
@zh-hant
name
The mechanism of folding of Im ...... etic evolutionary constraints.
@en
The mechanism of folding of Im ...... etic evolutionary constraints.
@en-gb
The mechanism of folding of Im ...... etic evolutionary constraints.
@nl
type
label
The mechanism of folding of Im ...... etic evolutionary constraints.
@en
The mechanism of folding of Im ...... etic evolutionary constraints.
@en-gb
The mechanism of folding of Im ...... etic evolutionary constraints.
@nl
prefLabel
The mechanism of folding of Im ...... etic evolutionary constraints.
@en
The mechanism of folding of Im ...... etic evolutionary constraints.
@en-gb
The mechanism of folding of Im ...... etic evolutionary constraints.
@nl
P2860
P50
P356
P1476
The mechanism of folding of Im ...... etic evolutionary constraints.
@en
P2093
D Alastair Smith
Joerg Gsponer
P2860
P2888
P304
P356
10.1038/NSMB.1562
P577
2009-03-01T00:00:00Z