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Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayOpening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle.Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.Kinetic evidence for unique regulation of GLUT4 trafficking by insulin and AMP-activated protein kinase activators in L6 myotubesIdentification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity.Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivoDirection pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathwayThe role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.Selective insulin resistance in adipocytesGLUT4 exocytosis.Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in AdipocytesGlobal Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes.mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signallingAdipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.Mapping insulin/GLUT4 circuitry.Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.Muscling in on GLUT4 kinetics.Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction.Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response.Re-fraction: a machine learning approach for deterministic identification of protein homologues and splice variants in large-scale MS-based proteomics.The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes.Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling.The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle.mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation.Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic DysfunctionMuscle and adipose tissue insulin resistance: malady without mechanism?Circulating AFABP promotes insulin secretionLipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolismMembrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1)Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to InsulinSerine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytesLactate production is a prioritized feature of adipocyte metabolismMitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
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Daniel Fazakerley
@nl
Daniel Fazakerley
@sl
P106
P21
P2798
P31
P496
0000-0001-8241-2903