Na+/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts.
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Activated NHE1 is required to induce early cardiac hypertrophy in miceElevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.Inhibition of Na+/H+-exchanger with sabiporide attenuates the downregulation and uncoupling of the myocardial beta-adrenoceptor system in failing rabbit hearts.Propranolol enhances cell cycle-related gene expression in pressure overloaded hearts.Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli.The cardiac Na-H exchanger: a key downstream mediator for the cellular hypertrophic effects of paracrine, autocrine and hormonal factors.The C57BL/6 genetic background confers cardioprotection in iron-overloaded miceNormalization of the calcineurin pathway underlies the regression of hypertensive hypertrophy induced by Na+/H+ exchanger-1 (NHE-1) inhibition.Elevated expression of activated Na(+)/H(+) exchanger protein induces hypertrophy in isolated rat neonatal ventricular cardiomyocytes.
P2860
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P2860
Na+/H+ exchange inhibition attenuates left ventricular remodeling and preserves systolic function in pressure-overloaded hearts.
description
2004 nî lūn-bûn
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2004年の論文
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name
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
@en
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
@nl
type
label
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
@en
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
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prefLabel
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
@en
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts.
@nl
P2093
P2860
P356
P1476
Na+/H+ exchange inhibition att ...... in pressure-overloaded hearts
@en
P2093
Alberto U Ferrari
Alessandro Vergari
Liviana Catalano
Marco Musumeci
Sergio Palazzesi
Tonino Stati
P2860
P304
P356
10.1038/SJ.BJP.0705631
P407
P577
2004-01-12T00:00:00Z