Theoretical analysis of interplay of therapeutic protein drug and circulating soluble target: temporal profiles of 'free' and 'total' drug and target.

Theoretical analysis of interplay of therapeutic protein drug and circulating soluble target: temporal profiles of 'free' and 'total' drug and target.

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http://www.wikidata.org/entity/Q43420262
ADME of biologics-what have we learned from small molecules?Factors influencing magnitude and duration of target inhibition following antibody therapy: implications in drug discovery and development.Bioanalysis of target biomarker and PK/PD relevancy during the development of biotherapeutics.Utility of free and total target measurements as target engagement and efficacy biomarkers in biotherapeutic development--opportunities and challenges.From the bench to clinical practice: understanding the challenges and uncertainties in immunogenicity testing for biopharmaceuticals.AFIR: A Dimensionless Potency Metric for Characterizing the Activity of Monoclonal Antibodies.Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling.Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.A Tutorial on Target-Mediated Drug Disposition (TMDD) Models.FG-3019, a Human Monoclonal Antibody Recognizing Connective Tissue Growth Factor, is Subject to Target-Mediated Drug Disposition.Free analyte QC concept: a novel approach to prove correct quantification of free therapeutic protein drug/biomarker concentrations.Mathematical simulations for bioanalytical assay development: the (un-)necessity and (im-)possibility of free drug quantification.Local versus systemic anti-tumour necrosis factor-α effects of adalimumab in rheumatoid arthritis: pharmacokinetic modelling analysis of interaction between a soluble target and a drug.The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density.
P2860

Theoretical analysis of interplay of therapeutic protein drug and circulating soluble target: temporal profiles of 'free' and 'total' drug and target.

Item
http://www.wikidata.org/entity/Q43420262
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2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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2011年學術文章
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name
Theoretical analysis of interp ...... ' and 'total' drug and target.
@en
Theoretical analysis of interp ...... ' and 'total' drug and target.
@nl
type
label
Theoretical analysis of interp ...... ' and 'total' drug and target.
@en
Theoretical analysis of interp ...... ' and 'total' drug and target.
@nl
prefLabel
Theoretical analysis of interp ...... ' and 'total' drug and target.
@en
Theoretical analysis of interp ...... ' and 'total' drug and target.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Theoretical analysis of interp ...... ' and 'total' drug and target.
@en
P2093
P2860
P304
P31
P356
P433
P478
P577
P698