2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest.
about
CD133 (Prominin) negative human neural stem cells are clonogenic and tripotentAntiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cellsSapacitabine for cancerOral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 studyPhase I dose-escalating study of TAS-106 in combination with carboplatin in patients with solid tumorsModified H5 promoter improves stability of insert genes while maintaining immunogenicity during extended passage of genetically engineered MVA vaccinesHomologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trialPhase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome.Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of SapacitabineThe impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analogHDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous LeukemiaSapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaksMechanism-Based Drug Combinations with the DNA Strand-Breaking Nucleoside Analog CNDAC.Acute myeloid leukemia in the elderly: do we know who should be treated and how?Profile of sapacitabine: potential for the treatment of newly diagnosed acute myeloid leukemia in elderly patients.TDP1 is critical for the repair of DNA breaks induced by sapacitabine, a nucleoside also targeting ATM- and BRCA-deficient tumors.Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations.Advances in the drug therapies of acute myeloid leukemia (except acute wpromyelocytic leukemia).Nucleobase and Nucleoside Analogues: Resistance and Re-Sensitisation at the Level of Pharmacokinetics, Pharmacodynamics and Metabolism
P2860
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P2860
2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G(2) arrest.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
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2001年学术文章
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2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
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2001年學術文章
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2001年學術文章
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name
2'-C-cyano-2'-deoxy-1-beta-D-a ...... s both DNA strand breaks and G
@nl
2'-C-cyano-2'-deoxy-1-beta-D-a ...... strand breaks and G(2) arrest.
@en
type
label
2'-C-cyano-2'-deoxy-1-beta-D-a ...... s both DNA strand breaks and G
@nl
2'-C-cyano-2'-deoxy-1-beta-D-a ...... strand breaks and G(2) arrest.
@en
prefLabel
2'-C-cyano-2'-deoxy-1-beta-D-a ...... s both DNA strand breaks and G
@nl
2'-C-cyano-2'-deoxy-1-beta-D-a ...... strand breaks and G(2) arrest.
@en
P2093
P1476
2'-C-cyano-2'-deoxy-1-beta-D-a ...... strand breaks and G(2) arrest.
@en
P2093
P304
P577
2001-04-01T00:00:00Z