Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: further evidence that thymidylate synthase is a half-of-the-sites activity enzyme.
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Mg 2+ Binds to the Surface of Thymidylate Synthase and Affects Hydride Transfer at the Interior Active SiteQM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthaseChemical shift imprint of intersubunit communication in a symmetric homodimer.Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases.Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study.Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase.Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.Significance of mutations on the structural perturbation of thymidylate synthase: implications for their involvement in subunit exchange.Toward rational design of species-specific inhibitors of Pneumocystis carinii thymidylate synthase and Toxoplasma gondii dihydrofolate reductase-thymidylate synthase.Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity.Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.Phosphorylation of thymidylate synthase affects slow-binding inhibition by 5-fluoro-dUMP and N(4)-hydroxy-dCMP.L55P transthyretin accelerates subunit exchange and leads to rapid formation of hybrid tetramers.
P2860
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P2860
Parameters affecting the restoration of activity to inactive mutants of thymidylate synthase via subunit exchange: further evidence that thymidylate synthase is a half-of-the-sites activity enzyme.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@en
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@nl
type
label
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@en
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@nl
prefLabel
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@en
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@nl
P2093
P356
P1433
P1476
Parameters affecting the resto ...... -of-the-sites activity enzyme.
@en
P2093
P304
P356
10.1021/BI002925X
P407
P577
2001-05-01T00:00:00Z