Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
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Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthaseCrystal Structure of Liganded Rat Peroxisomal Multifunctional Enzyme Type 1: A FLEXIBLE MOLECULE WITH TWO INTERCONNECTED ACTIVE SITESFirst Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase–Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate ChannelingElectrostatic channeling in P. falciparum DHFR-TS: Brownian dynamics and Smoluchowski modeling.Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis.Substrate channeling between the human dihydrofolate reductase and thymidylate synthase.Selective peptide inhibitors of bifunctional thymidylate synthase-dihydrofolate reductase from Toxoplasma gondii provide insights into domain-domain communication and allosteric regulation.
P2860
Q27642334-0CFDA091-6679-4F04-A21E-9E6A13D838E8Q27661574-750AA811-3D07-4D2A-B04A-A25D43FBC636Q27680002-445691C2-7F7A-46A8-90B1-62391D504068Q34561303-76E4F5F8-7B88-4C6B-86C1-A23ECE335F31Q37403841-E878A79D-44B2-49F2-A08F-B954391A4C98Q39721460-B9816841-4844-4E75-972D-8FBF7EBC3E95Q42632086-05FF7AA9-B8E5-4AC3-835A-712764F2C5EC
P2860
Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
description
2003 nî lūn-bûn
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name
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@en
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@nl
type
label
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@en
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@nl
prefLabel
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@en
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@nl
P2093
P2860
P356
P1476
Probing electrostatic channeli ...... ing site-directed mutagenesis.
@en
P2093
Chloé E Atreya
Eric F Johnson
Jessica Williamson
Karen S Anderson
Po-Huang Liang
Sing-Yang Chang
P2860
P304
28901-28911
P356
10.1074/JBC.M212689200
P407
P577
2003-05-17T00:00:00Z