Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.
about
Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysisRole of protein-protein interactions in cytochrome P450-mediated drug metabolism and toxicityExperimental approaches to evaluate activities of cytochromes P450 3ARate-limiting steps in cytochrome P450 catalysis.The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.Intracellular drug bioavailability: a new predictor of system dependent drug disposition.A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches.Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5).The action of cytochrome b(5) on CYP2E1 and CYP2C19 activities requires anionic residues D58 and D65.Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activitiesSubstrate-modulated cytochrome P450 17A1 and cytochrome b5 interactions revealed by NMR.Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activityP450 reductase and cytochrome b5 interactions with cytochrome P450: effects on house fly CYP6A1 catalysis.Structural diversity of cytochrome P450 enzyme system.Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions.Identification of the interactions between cytochrome P450 2E1 and cytochrome b5 by mass spectrometry and site-directed mutagenesis.The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.Optimalization of preparation of apo-cytochrome b(5) utilizing apo-myoglobin.Defining the in Vivo Role for cytochrome b5 in cytochrome P450 function through the conditional hepatic deletion of microsomal cytochrome b5.Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity.Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.Analysis of the interactions of cytochrome b5 with flavocytochrome P450 BM3 and its domains.Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9.Structural and functional effects of cytochrome b5 interactions with human cytochrome P450 enzymes.Taxadiene-5α-ol is a minor product of CYP725A4 when expressed in Escherichia coli.
P2860
Q28305458-DC2A3A7E-9E0C-4506-8154-ED4CFD87E3F6Q28568816-E869F171-DE55-487B-B155-F1A8C6CE6C6DQ34181972-8AFA7D27-EC47-4DD6-A4B9-8B5D30D3F37FQ34359626-58F2AD27-972C-432E-988D-6EF4BF7AF0F3Q35009284-A8541B9B-CF57-4150-B8DC-56F68AD54727Q35016427-53175CA5-507E-4641-9B3F-21295C04AEBEQ36287236-AAAFB8BC-9B9F-4221-9118-49622179A86BQ36324758-3E85B0A7-4FE9-4D37-B0EC-080C37D0CD9AQ36598930-4855AA2E-99C1-46BF-8206-5EB9D7FDE186Q36680194-2C7AC524-EC33-43A9-A6AD-0E0FDFC99669Q36700755-06D83C56-DF7E-463A-B45D-1C424EE9ED01Q36910210-24B624FF-22CD-4D42-80F9-7898316411B8Q36952243-D2FC8CD1-C975-4BBE-BDE0-F5F7A33CFF8CQ37121037-98250B49-326D-4DE0-8D07-F372FB42BFDEQ37672815-4EACE74F-E972-4492-9815-749E6C0FECFDQ37852000-2E3D4AFA-C86F-4314-B68B-E5158515D7A4Q38313562-49AF1520-8FA9-48B0-B443-40F085127BF5Q39148039-570AE1B8-542F-4187-8007-78FE8DD4B3FEQ41451298-91BCE0ED-659E-4C09-A143-597A9382FC5AQ41824446-832E6E06-DEDD-42FB-945A-3CE72D0BA0D0Q43710136-EC37B9B3-98C0-4BF2-86C1-55C51C65D25EQ44457504-7DC7A17C-5E81-49F7-997A-6D47533253EAQ46894744-8EA43D38-A900-4AB7-BDEA-79FEA68DA14BQ47349033-4A86E78E-D2BD-47FB-9381-261F1CE73875Q47592827-1A1F8C61-0B05-411D-97B9-D78B034DEA31Q47710758-B1CD1557-CC9C-4C7A-A4BE-9E8D5DF7863B
P2860
Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@en
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@nl
type
label
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@en
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@nl
prefLabel
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@en
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@nl
P2093
P2860
P356
P1476
Stimulation of cytochrome P450 ...... tochrome b5 or heme oxygenase.
@en
P2093
F P Guengerich
M V Martin
P2860
P304
30885-30891
P356
10.1074/JBC.M105011200
P407
P577
2001-06-18T00:00:00Z