The volume of distribution is an indicator of poor in vitro-in vivo extrapolation of clearance for acidic drugs in the rat.

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The volume of distribution is an indicator of poor in vitro-in vivo extrapolation of clearance for acidic drugs in the rat.

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2013 nî lūn-bûn

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2013年学术文章

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The volume of distribution is ...... e for acidic drugs in the rat.

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The volume of distribution is ...... e for acidic drugs in the rat.

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The volume of distribution is ...... e for acidic drugs in the rat.

@en

The volume of distribution is ...... e for acidic drugs in the rat.

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The volume of distribution is ...... e for acidic drugs in the rat.

@en

The volume of distribution is ...... e for acidic drugs in the rat.

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P1476

The volume of distribution is ...... e for acidic drugs in the rat.

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P2093

Anna-Karin Sohlenius-Sternbeck

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Johan Bylund

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Urban Fagerholm

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P2860

Use of a cocktail of probe substrates for drug-metabolizing enzymes for the assessment of the metabolic capacity of hepatocyte preparations.

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches.

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.

Interspecies prediction of human drug clearance based on scaling data from one or two animal species.

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry.

Phenotypic stability of adult rat hepatocytes in primary monolayer culture.

Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships.

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.

P304

671-678

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P31

scholarly article

P356

10.3109/00498254.2012.755578

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English

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P478

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P577

2013-01-16T00:00:00Z

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P698

23323549

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