Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.
about
Assessment of in silico models for fraction of unbound drug in human liver microsomes.A systems biology approach to dynamic modeling and inter-subject variability of statin pharmacokinetics in human hepatocytes.Toxicokinetic Triage for Environmental Chemicals.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Quantitative structure-pharmacokinetic relationships.The role of drug metabolizing enzymes in clearance.An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library.Comparison of methods for the prediction of human clearance from hepatocyte intrinsic clearance for a set of reference compounds and an external evaluation set.A Fragment-Based Approach for the Computational Prediction of the Nonspecific Binding of Drugs to Hepatic Microsomes.Are there differences in the catalytic activity per unit enzyme of recombinantly expressed and human liver microsomal cytochrome P450 2C9? A systematic investigation into inter-system extrapolation factors.Prediction of drug-drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition.Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma.Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.Structure-based prediction of the nonspecific binding of drugs to hepatic microsomes.Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions.The volume of distribution is an indicator of poor in vitro-in vivo extrapolation of clearance for acidic drugs in the rat.Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats.In vitro metabolism of the lignan (-)-grandisin, an anticancer drug candidate, by human liver microsomes.Drug Distribution. Part 1. Models to Predict Membrane Partitioning.Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.Online monitoring of hepatic rat metabolism by coupling a liver biochip and a mass spectrometer.Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.Prediction of Metabolic Clearance for Low-Turnover Compounds Using Plated Hepatocytes with Enzyme Activity Correction.httk: R Package for High-Throughput Toxicokinetics
P2860
Q33541186-6DD72F57-82CB-4250-84F5-4DB6E4ACE552Q33891588-606BFDFB-42F4-4D5B-AF9C-98F3750F3CC6Q36027800-BA4FCF28-5A7D-4263-B0F2-35E28D75A983Q36204768-833B1FF6-8EF7-48B4-9E0F-B928DCA9757FQ37812139-D130438C-EAC5-4E2D-A46D-83F8AF78A3D4Q38176051-744E36D3-D8C3-4E27-93B1-E77982FD1733Q38624509-79453058-26A5-4FF8-AD3C-31987A87F0C2Q39454404-0B09A9A1-15CA-4A71-8590-4BA7341506E9Q39471808-B42BD1BC-AD3C-47A6-9B40-6B9123C97251Q39732707-40881BD1-9846-4114-A696-9D876A6141C6Q39952608-BDF6608E-759A-4F69-B087-9030715F0D8AQ40003126-6ABA92ED-5F80-464D-97DD-3BAFE9091A8FQ40018596-3CB1320B-63B2-4600-B41B-DBE2F22F95B6Q41582110-B1A2AAE4-5B90-4F3D-BBDB-A340A8B55A27Q43117322-C089CC8A-96DE-4274-BB15-9C1E38E45362Q43424784-D656F2F9-5C30-4FD7-86B8-4D05443FDE74Q43662714-8955C6C2-E7C5-48E0-BE95-44FDA729D4E8Q44731939-658E1095-D898-47BD-BCBE-820F9BA8E6E1Q45008232-3B50656F-0107-41C8-BC49-EACA5A66823BQ46445351-C94DFD4C-012D-41C1-BB39-949040EBCCEAQ47893797-5AC94967-BB8D-4E00-814D-B7AA057EB2C0Q48004624-28AD2C04-D024-400D-97CC-DFBEF300F8DEQ50785453-F904D0FE-3DCD-4E6C-A239-CF3F25DB83BAQ53117894-FE28693C-D467-4E46-AA9A-BD6E4C24C8E4Q56983482-9BE6D8E6-6B75-4836-A6DD-734ED5E9216A
P2860
Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@ast
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@en
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@nl
type
label
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@ast
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@en
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@nl
prefLabel
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@ast
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@en
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@nl
P2093
P356
P1476
Hepatocellular binding of drug ...... ng or drug lipophilicity data.
@en
P2093
J Brian Houston
Michael Gertz
Peter J Kilford
P304
P356
10.1124/DMD.108.020834
P577
2008-04-14T00:00:00Z