Cellular membrane composition defines A beta-lipid interactions.
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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.Disrupting self-assembly and toxicity of amyloidogenic protein oligomers by "molecular tweezers" - from the test tube to animal modelsPresenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membranePreferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shiftRapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomesInteraction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease.How does plasmid DNA penetrate cell membranes in artificial transformation process of Escherichia coli?Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta proteinAn apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42Molecular insights into amyloid regulation by membrane cholesterol and sphingolipids: common mechanisms in neurodegenerative diseasesWeak glycolipid binding of a microdomain-tracer peptide correlates with aggregation and slow diffusion on cell membranes.Lipid-induced beta-amyloid peptide assemblage fragmentationFusogenic Alzheimer's peptide fragment Abeta (29-42) in interaction with lipid bilayers: secondary structure, dynamics, and specific interaction with phosphatidyl ethanolamine polar heads as revealed by solid-state NMR.How Do the Size, Charge and Shape of Nanoparticles Affect Amyloid β Aggregation on Brain Lipid Bilayer?Promotion of oxidative lipid membrane damage by amyloid beta proteinsFollowing activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Impact of GM1 on Membrane-mediated Aggregation/Oligomerization of β-amyloid: Unifying View.Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2.Stabilization of discordant helices in amyloid fibril-forming proteinsCholesterol modulates the interaction of beta-amyloid peptide with lipid bilayersMacroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.pH-Dependent Interaction between C-Peptide and Phospholipid BicellesInsertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E.Impacts of membrane biophysics in Alzheimer's disease: from amyloid precursor protein processing to aβ Peptide-induced membrane changes.Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.Cholesterol is necessary both for the toxic effect of Abeta peptides on vascular smooth muscle cells and for Abeta binding to vascular smooth muscle cell membranes.The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids.Behavioral and neurochemical effects of the intrahippocampal co-injection of beta-amyloid protein 1-40 and ibotenic acid in rats.Biophysical characterization of longer forms of amyloid beta peptides: possible contribution to flocculent plaque formation.Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Abeta(1-40) peptide in solid-supported lipid bilayers.Adsorption of Amyloid β (1-40) Peptide at Phospholipid MonolayersSelf-aggregation – an intrinsic property of GM1in lipid bilayers
P2860
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P2860
Cellular membrane composition defines A beta-lipid interactions.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Cellular membrane composition defines A beta-lipid interactions.
@en
Cellular membrane composition defines A beta-lipid interactions.
@nl
type
label
Cellular membrane composition defines A beta-lipid interactions.
@en
Cellular membrane composition defines A beta-lipid interactions.
@nl
prefLabel
Cellular membrane composition defines A beta-lipid interactions.
@en
Cellular membrane composition defines A beta-lipid interactions.
@nl
P2093
P2860
P356
P1476
Cellular membrane composition defines A beta-lipid interactions.
@en
P2093
P2860
P304
33561-33568
P356
10.1074/JBC.M103598200
P407
P577
2001-07-03T00:00:00Z