Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
about
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzymeInsights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside PhosphorylasesSubstrate Deconstruction and the Nonadditivity of Enzyme RecognitionThe Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.Identification and characterization of a unique adenosine kinase from Mycobacterium tuberculosis6-Oxo and 6-thio purine analogs as antimycobacterial agents.Identification and characterization of two adenosine phosphorylase activities in Mycobacterium smegmatis.Crystallization and preliminary X-ray diffraction analysis of prephenate dehydratase from Mycobacterium tuberculosis H37Rv.Adenine release is fast in MutY-catalyzed hydrolysis of G:A and 8-Oxo-G:A DNA mismatches.Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.Conformational adaptation in drug-target interactions and residence time.New Insights into Active Site Conformation Dynamics of E. coli PNP Revealed by Combined H/D Exchange Approach and Molecular Dynamics Simulations.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidases.An Immucillin-Based Transition-State-Analogous Inhibitor of tRNA-Guanine Transglycosylase (TGT).
P2860
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P2860
Purine nucleoside phosphorylase from Mycobacterium tuberculosis. Analysis of inhibition by a transition-state analogue and dissection by parts.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@en
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@nl
type
label
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@en
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@nl
prefLabel
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@en
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@nl
P2093
P356
P1433
P1476
Purine nucleoside phosphorylas ...... logue and dissection by parts.
@en
P2093
P304
P356
10.1021/BI010584X
P407
P577
2001-07-01T00:00:00Z