The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.
about
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.A simple and mild synthesis of 1H-isochromenes and (Z)-1-alkylidene-1,3-dihydroisobenzofurans by the iodocyclization of 2-(1-alkynyl)benzylic alcohols.Iodine/palladium approaches to the synthesis of polyheterocyclic compounds.Naphthalene combretastatin analogues: synthesis, cytotoxicity and antitubulin activity.Synthesis of 2,3-disubstituted benzo[b]selenophenes via electrophilic cyclization.Synthesis of 3,4-disubstituted 2H-benzopyrans through C-C bond formation via electrophilic cyclizationAn overview of tubulin inhibitors that interact with the colchicine binding siteCompetition studies in alkyne electrophilic cyclization reactionsHighly potent triazole-based tubulin polymerization inhibitors.Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3″,4″,5″-trimethoxybenzoyl)-6-methoxyindole (OXi8006)Biomedical importance of indoles.Recent advances in the synthesis of thiophene derivatives by cyclization of functionalized alkynes.Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors.Iodine-mediated synthesis of heterocycles via electrophilic cyclization of alkynes.Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.Synthesis of densely functionalised 5-halogen-1,3-oxazin-2-ones by halogen-mediated regioselective cyclisation of N-Cbz-protected propargylic amines: a combined experimental and theoretical study.Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation.Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold.Regioselective 5-endo-dig Electrophilic Iodocyclization of Enediynes: A Convenient Route to Iodo-substituted Indenes and Cyclopenta-Fused Arenes.
P2860
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P2860
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@en
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@nl
type
label
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@en
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@nl
prefLabel
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@en
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@nl
P2093
P1476
The synthesis and tubulin bind ...... alogues of combretastatin A-4.
@en
P2093
P304
P356
10.1016/S0960-894X(01)00436-X
P407
P577
2001-09-01T00:00:00Z