Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. - Wikidata - awgldk - TriplyDB

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

http://www.wikidata.org/entity/Q43734888

about

Salinomycin as a drug for targeting human cancer stem cells Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression P21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells Kita driven expression of oncogenic HRAS leads to early onset and highly penetrant melanoma in zebrafish Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα p21 in cancer: intricate networks and multiple activities The therapeutic promise of the cancer stem cell concept.HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation.Deletion of Puma protects hematopoietic stem cells and confers long-term survival in response to high-dose gamma-irradiation.Heating cancer stem cells to reduce tumor relapse.Hepatitis C virus NS5B protein delays s phase progression in human hepatocyte-derived cells by relocalizing cyclin-dependent kinase 2-interacting protein (CINP).Identification and targeting of cancer stem cells.Bmi1 regulates mitochondrial function and the DNA damage response pathway Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres.Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells.DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions.IKAROS deletions dictate a unique gene expression signature in patients with adult B-cell acute lymphoblastic leukemia L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.Nestin positively regulates the Wnt/β-catenin pathway and the proliferation, survival and invasiveness of breast cancer stem cells.EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells AMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts.STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.Radioresistance of cancer stem-like cell derived from canine tumours.CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myeloma Polycomb protein EZH2 regulates cancer cell fate decision in response to DNA damage.Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1 The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal Regulation of murine hematopoietic stem cell quiescence by Dmtf1 The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors.Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells.Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells.

http://www.wikidata.org/entity/Q43734888

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

@zh-my

2009年学术文章

@zh-sg

2009年學術文章

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2009年學術文章

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2009年學術文章

@zh-hant

name

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@en

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@nl

type

label

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@en

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@nl

prefLabel

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@en

Cell-cycle restriction limits ...... newal of leukaemia stem cells.

@nl

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Cell-cycle restriction limits ...... newal of leukaemia stem cells.

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Alberto Gobbi

http://www.w3.org/2001/XMLSchema#string

Andrea Viale

http://www.w3.org/2001/XMLSchema#string

Annette Orleth

http://www.w3.org/2001/XMLSchema#string

Francesca De Franco

http://www.w3.org/2001/XMLSchema#string

Ivan Muradore

http://www.w3.org/2001/XMLSchema#string

Pier Giuseppe Pelicci

http://www.w3.org/2001/XMLSchema#string

Saverio Minucci

http://www.w3.org/2001/XMLSchema#string

Silvia Monestiroli

http://www.w3.org/2001/XMLSchema#string

Simona Ronzoni

http://www.w3.org/2001/XMLSchema#string

Valeria Cambiaghi

http://www.w3.org/2001/XMLSchema#string

P2860

Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

DNA repair is limiting for haematopoietic stem cells during ageing

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

Cellular senescence: when bad things happen to good cells

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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51-56

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scholarly article

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10.1038/NATURE07618

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P433

7225

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P478

457

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Chiara Ronchini

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2009-01-01T00:00:00Z

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19122635

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