Letter: Synthesis of (+/-)-7 beta,8alpha-dihydroxy-9 beta,10beta-epoxy-7,8,-9,10-tetrahydrobenzo(a)pyrene, a potential metabolite of the carcinogen benzo(a)pyrene with stereochemistry related to the antileukemic triptolides.
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Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Crystal and molecular structure of a benzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct: absolute configuration and conformationElucidation of hydrocarbon structure in an enzyme-catalyzed benzo[a]pyrene-poly (G) covalent complex.Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyreneMetabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.(+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo (a)pyrene: a potent skin carcinogen when applied topically to miceMutagenicity and cytotoxicity of benz[alpha]anthracene diol epoxides and tetrahydro-epoxides: exceptional activity of the bay region 1,2-epoxidesIdentification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.Mechanism of the inhibition of mutagenicity of a benzo[a]pyrene 7,8-diol 9,10-epoxide by riboflavin 5'-phosphateInhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: exceptional activity of ellagic acidEpoxidation of (+/-)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene during (bi)sulfite autoxidation: activation of a procarcinogen by a cocarcinogen.Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.Pathways involved in the metabolism and activation of polycyclic hydrocarbons.Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens.A single site-specific trans-opened 7,8,9,10-tetrahydrobenzo[a]pyrene 7,8-diol 9,10-epoxide N2-deoxyguanosine adduct induces mutations at multiple sites in DNA.Hydrogen-bonded intermediates and transition states during spontaneous and acid-catalyzed hydrolysis of the carcinogen (+)-anti-BPDE.Toxic agents resulting from the oxidative metabolism of steroid hormones and drugs.New facile enantio- and diastereo-selective syntheses of (-)-triptonide and (-)-triptolide.Double-stranded DNA stereoselectively binds benzo(a)pyrene diol epoxidesStructures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants
P2860
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P2860
Letter: Synthesis of (+/-)-7 beta,8alpha-dihydroxy-9 beta,10beta-epoxy-7,8,-9,10-tetrahydrobenzo(a)pyrene, a potential metabolite of the carcinogen benzo(a)pyrene with stereochemistry related to the antileukemic triptolides.
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1975 nî lūn-bûn
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1975年の論文
@ja
1975年学术文章
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1975年学术文章
@zh-cn
1975年学术文章
@zh-hans
1975年学术文章
@zh-my
1975年学术文章
@zh-sg
1975年學術文章
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1975年學術文章
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1975年學術文章
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name
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@en
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@nl
type
label
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@en
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@nl
prefLabel
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@en
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@nl
P2093
P356
P1476
Letter: Synthesis of (+/-)-7 b ...... the antileukemic triptolides.
@en
P2093
P304
P356
10.1021/JA00856A057
P407
P577
1975-11-01T00:00:00Z