Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma.
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Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinomaIdentification of a CpG island methylator phenotype that defines a distinct subgroup of gliomaEmerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancerGlioma Malignancy-Dependent NDRG2 Gene Methylation and Downregulation Correlates with Poor Patient Outcome.Expression profiling in canine osteosarcoma: identification of biomarkers and pathways associated with outcome.Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer.Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression.FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model.The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway.Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation.NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patients.Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinomaNDRG4 is downregulated in glioblastoma and inhibits cell proliferation.Expression of merlin, NDRG2, ERBB2, and c-MYC in meningiomas: relationship with tumor grade and recurrence.Personalized treatment strategies in glioblastoma: MGMT promoter methylation status.AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells.NDRG4 is required for cell cycle progression and survival in glioblastoma cells.Molecular neuropathology of gliomas.Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.N-myc downstream-regulated gene 2 (NDRG2) promoter methylation and expression in pituitary adenomaUnraveling the glioma epigenome: from molecular mechanisms to novel biomarkers and therapeutic targets.Deregulated chromatin remodeling in the pathobiology of brain tumors.DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas.N-myc downstream-regulated gene 2 in the nervous system: from expression pattern to function.Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers.An update on the epigenetics of glioblastomas.DNA methylation of NDRG2 in gastric cancer and its clinical significance.NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas.Regulation of histone acetylation by NDRG2 in glioma cells.The effect of oncoprotein v-erbA on thyroid hormone-regulated genes in hepatocytes and their potential role in hepatocellular carcinoma.In Silico Enhanced Restriction Enzyme Based Methylation Analysis of the Human Glioblastoma Genome Using Agilent 244K CpG Island Microarrays.Expression and prognostic value of the aldehyde dehydrogenase 1 (ALDH1) and N-myc downstream regulated gene 2 (NDRG2) as potential markers in human astrocytomas.Lipocalin 2 (LCN2) is a promising target for cholangiocarcinoma treatment and bile LCN2 level is a potential cholangiocarcinoma diagnostic markerThe methylation of a panel of genes differentiates low-grade from high-grade gliomas.Beyond Genetics in Glioma Pathways: The Ever-Increasing Crosstalk between Epigenomic and Genomic EventsSynergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP CellsPromoter methylation of AREG, HOXA11, hMLH1, NDRG2, NPTX2 and Tes genes in glioblastoma.Recent Advances in Understanding Cholangiocarcinoma.Loss of NDRG2 in liver microenvironment inhibits cancer liver metastasis by regulating tumor associate macrophages polarization.N-myc downstream-regulated gene 2 inhibits human cholangiocarcinoma progression and is regulated by leukemia inhibitory factor/MicroRNA-181c negative feedback pathway.
P2860
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P2860
Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@en
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@nl
type
label
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@en
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@nl
prefLabel
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@en
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@nl
P2093
P2860
P50
P356
P1476
Frequent promoter hypermethyla ...... q11.2 in primary glioblastoma.
@en
P2093
David H Gutmann
Markus J Riemenschneider
Martin Tepel
Peter Roerig
P2860
P304
P356
10.1002/IJC.23705
P577
2008-11-01T00:00:00Z