Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug.
about
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.Mitochondria, cholesterol and cancer cell metabolismMechanisms of ferroptosisIncreased Oxidative Stress as a Selective Anticancer TherapyMyeloid-derived suppressor cells and anti-tumor T cells: a complex relationshipSLC transporters as therapeutic targets: emerging opportunitiesFerroptosis, a new form of cell death, and its relationships with tumourous diseasesIdentifying prognostic features by bottom-up approach and correlating to drug repositioningHigh-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma CellsCD44 variant-dependent redox status regulation in liver fluke-associated cholangiocarcinoma: A target for cholangiocarcinoma treatment.Genomic analysis of xCT-mediated regulatory network: Identification of novel targets against AIDS-associated lymphoma.Targeting xCT, a cystine-glutamate transporter induces apoptosis and tumor regression for KSHV/HIV-associated lymphomaMyeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine.Identification of capsazepine as a novel inhibitor of system xc- and cancer-induced bone pain.The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.The redox status of cystinotic fibroblasts.Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosisNew insights into redox homeostasis as a therapeutic target in B-cell malignancies.Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer.Antigen-presenting cells control T cell proliferation by regulating amino acid availability.Ferroptosis: an iron-dependent form of nonapoptotic cell deathDownregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts.Ferroptosis: Death by Lipid Peroxidation.Ferroptosis: process and function.System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.Sulfasalazine and mesalamine modulate beryllium-specific lymphocyte proliferation and inflammatory cytokine production.The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.LLW-3-6 and celecoxib impacts growth in prostate cancer cells and subcellular localization of COX-2.Behavioral assessment of acute inhibition of system xc (-) in ratsRedox-based therapeutics in neurodegenerative disease.Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-kappaB.Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support.Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain.xCT, not just an amino-acid transporter: a multi-functional regulator of microbial infection and associated diseasesThiol redox homeostasis in neurodegenerative diseaseStromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemiaAutocrine glutamate signaling promotes glioma cell invasion.In Vivo Loss of Function Screening Reveals Carbonic Anhydrase IX as a Key Modulator of Tumor Initiating Potential in Primary Pancreatic Tumors.Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses
P2860
Q24536188-F3ACBFD7-75C5-425D-AFC5-6FA9B423A5D4Q26741708-F338268A-B538-4552-B973-6B1EEA2468C1Q26751418-8E594C59-7E16-4951-84EF-91841059D7FFQ26798210-5E368003-234D-4A64-9C37-6BB8A5433B01Q27000087-69CAE0A4-B1C1-4644-9C22-EB76DF0F791CQ27014726-3687DBD6-81A9-46BC-8EEE-83C7A6E88444Q28076336-7AC63695-345F-4292-9AFD-B2B2C956DFB6Q28543844-97D16BC8-CF8A-450E-8107-84BD4AB2065EQ28547125-1C7B68A7-9C7B-4A12-A08C-EAE8422C93F9Q30378139-A78A75AD-2CFC-42BB-929A-5189D118F536Q30379938-738CBEA8-9E6D-43F3-9EA4-0A0AE9ADC0C6Q30409463-B619BBCD-A421-48BF-8535-7C80F4053BA4Q33584867-A12979A1-9EC6-49B0-806C-01B9D9B727A3Q33596824-A16EEC3A-61F7-4395-B6AE-4137AEA32BD8Q33628932-A556118E-3B82-45A7-A228-B61016497668Q33728336-D04B72E1-06FD-4A79-9280-B9F4A98ADB05Q33729597-153C149D-F759-4E5E-A512-F901E52CFA6BQ33745283-2D7E4C2C-A09D-422F-BEEB-CDE4A30A8F06Q33797951-AADC475B-CB2B-4B1B-AD36-ED319E3B45EFQ33894596-98CDE172-CCB9-4DD1-BBFB-76A186C7141FQ34008226-E4FD2ED5-B768-4B56-90BE-E4097910947DQ34032093-634EE025-32CC-4B4A-9AE6-33E5FD49756DQ34038268-40E15F6A-F59E-45DB-B1DB-2C4EACC53A3BQ34045575-0AC3083B-452E-45F5-8B83-91662EEC555AQ34045909-AADC357F-0814-4E5E-BE93-868DD472826FQ34184493-88D688A2-E2A0-430D-814B-B5DAB232B30BQ34184827-A3058A27-1183-468D-A5DD-67C3CA91D97CQ34279067-6CFF60BD-C310-4BCB-BF9B-9A249C3266ACQ34379252-FC109218-5701-4028-AAD6-D6B618B90BD6Q34420036-A754C4EB-7DBF-49AB-AE8C-266D060434D1Q34535918-4C6103B3-5915-4086-BDFE-03C8AFC5CDBBQ34543666-27232E7D-B258-41F9-972D-66ACCF5D31AFQ34957024-5CCB37EB-75B7-4D9C-8EC7-054ECBBFA597Q35070083-5DEABB09-2906-48C4-A152-42F512CCFCC8Q35099427-8D7EEE86-32E1-4DCE-A975-F9AE40772DC7Q35614227-FD4A5BC0-925F-44B6-B458-0B634B44F1D5Q35791336-DA08C669-786A-46A8-9D4C-236CD7357F28Q36098125-5B2BA0EC-21D7-449D-8748-E8B11A0E9E25Q36480199-D206C4B2-09E7-4C0A-9560-5FB0EA516545Q36780705-F6CDFAFA-8848-4015-89EB-6F4C8F8D97BE
P2860
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@en
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@nl
type
label
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@en
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@nl
prefLabel
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@en
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@nl
P2093
P356
P1433
P1476
Sulfasalazine, a potent suppre ...... a new action for an old drug.
@en
P2093
P2888
P304
P356
10.1038/SJ.LEU.2402238
P577
2001-10-01T00:00:00Z
P5875
P6179
1035259405