Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer. - Wikidata - awgldk - TriplyDB

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.

http://www.wikidata.org/entity/Q43761459

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Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells.RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.Induction of FLIP expression by androgens protects prostate cancer cells from TRAIL-mediated apoptosis Akt activity protects rheumatoid synovial fibroblasts from Fas-induced apoptosis by inhibition of Bid cleavage High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)Akt-phosphorylated mitogen-activated kinase-activating death domain protein (MADD) inhibits TRAIL-induced apoptosis by blocking Fas-associated death domain (FADD) association with death receptor 4 Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer.EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.TRAIL in cancer therapy: present and future challenges.Selenocysteine derivative overcomes TRAIL resistance in melanoma cells: evidence for ROS-dependent synergism and signaling crosstalk.The inhibition of Bid expression by Akt leads to resistance to TRAIL-induced apoptosis in ovarian cancer cells.Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells.A protein kinase C/protein kinase D pathway protects LNCaP prostate cancer cells from phorbol ester-induced apoptosis by promoting ERK1/2 and NF-{kappa}B activities Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis.Ruthenium polypyridyl complex inhibits growth and metastasis of breast cancer cells by suppressing FAK signaling with enhancement of TRAIL-induced apoptosis.STAMP2 increases oxidative stress and is critical for prostate cancer.Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells.Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.Targeted ovarian cancer treatment: the TRAILs of resistance.Nonautophagic cytoplasmic vacuolation death induction in human PC-3M prostate cancer by curcumin through reactive oxygen species -mediated endoplasmic reticulum stress Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment.TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential.Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis.Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death Glycogen synthase kinase-3β regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-κB pathway in hepatocellular carcinoma.Curcumin sensitizes TRAIL-resistant xenografts: molecular mechanisms of apoptosis, metastasis and angiogenesis 5,7-Dihydroxyflavone Enhances the Apoptosis-Inducing Potential of TRAIL in Human Tumor Cells via Regulation of Apoptosis-Related Proteins Niacin alleviates TRAIL-mediated colon cancer cell death via autophagy flux activation.Role of mTOR in anticancer drug resistance: perspectives for improved drug treatment.Astroglial PTEN Loss Disrupts Neuronal Lamination by Dysregulating Radial Glia-guided Neuronal Migration Myocardial AKT: the omnipresent nexus.Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer.

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Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.

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P2860

Molecular characterization of mitochondrial apoptosis-inducing factor

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Characterization of two receptors for TRAIL

The receptor for the cytotoxic ligand TRAIL

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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