Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts.
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Cariporide given during resuscitation promotes return of electrically stable and mechanically competent cardiac activity.Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injuryTargeting mitochondria for resuscitation from cardiac arrest.Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillationRole of dopamine D2 receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes.Adding ROS quenchers to cold K+ cardioplegia reduces superoxide emission during 2-hour global cold cardiac ischemia.Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated heartsDamage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine.Protecting mitochondrial bioenergetic function during resuscitation from cardiac arrest.Reduced mitochondrial Ca2+ loading and improved functional recovery after ischemia-reperfusion injury in old vs. young guinea pig hearts.The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice.AVE4454B--a novel sodium-hydrogen exchanger isoform-1 inhibitor--compared less effective than cariporide for resuscitation from cardiac arrest.Enhanced Na+/H+ exchange during ischemia and reperfusion impairs mitochondrial bioenergetics and myocardial functionModulation of mitochondrial bioenergetics in the isolated Guinea pig beating heart by potassium and lidocaine cardioplegia: implications for cardioprotection.Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure.The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study.Mg(2+) differentially regulates two modes of mitochondrial Ca(2+) uptake in isolated cardiac mitochondria: implications for mitochondrial Ca(2+) sequestration.Cardiac preconditioning with 4-h, 17 degrees C ischemia reduces [Ca(2+)](i) load and damage in part via K(ATP) channel opening.Anesthetic preconditioning: triggering role of reactive oxygen and nitrogen species in isolated hearts.Altered NADH and improved function by anesthetic and ischemic preconditioning in guinea pig intact hearts.Cross-bridge kinetics modeled from myoplasmic [Ca2+] and LV pressure at 17 degrees C and after 37 degrees C and 17 degrees C ischemia.Adverse postresuscitation myocardial effects elicited by buffer-induced alkalemia ameliorated by NHE-1 inhibition in a rat model of ventricular fibrillation.Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse.Na+/H+ exchange inhibitor cariporide attenuates skeletal muscle infarction when administered before ischemia or reperfusion.Endogenous and Agonist-induced Opening of Mitochondrial Big Versus Small Ca2+-sensitive K+ Channels on Cardiac Cell and Mitochondrial Protection.Functional diversity of electrogenic Na+-HCO3- cotransport in ventricular myocytes from rat, rabbit and guinea pig.Limiting sarcolemmal Na+ entry during resuscitation from ventricular fibrillation prevents excess mitochondrial Ca2+ accumulation and attenuates myocardial injury.Exercise alters the regulation of myocardial Na(+)/H(+) exchanger-1 activity.
P2860
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P2860
Blocking Na(+)/H(+) exchange reduces [Na(+)](i) and [Ca(2+)](i) load after ischemia and improves function in intact hearts.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Blocking Na
@nl
Blocking Na(+)/H(+) exchange r ...... ves function in intact hearts.
@en
type
label
Blocking Na
@nl
Blocking Na(+)/H(+) exchange r ...... ves function in intact hearts.
@en
prefLabel
Blocking Na
@nl
Blocking Na(+)/H(+) exchange r ...... ves function in intact hearts.
@en
P2093
P2860
P1476
Blocking Na(+)/H(+) exchange r ...... ves function in intact hearts.
@en
P2093
Novalija E
Varadarajan SG
P2860
P304
P356
10.1152/AJPHEART.2001.281.6.H2398
P577
2001-12-01T00:00:00Z