Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein.
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The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complexThe nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processingEpstein-Barr virus latent membrane protein 1 (LMP1) C-terminal-activating region 3 contributes to LMP1-mediated cellular migration via its interaction with Ubc9Distinct in vivo dynamics of vertebrate SUMO paraloguesG2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localizationThe RNA Splicing Response to DNA DamageIn vivo modeling of polysumoylation uncovers targeting of Topoisomerase II to the nucleolus via optimal level of SUMO modificationGene disruption of the DNA topoisomerase IB small subunit induces a non-viable phenotype in the hemoflagellate Leishmania majorA proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58.The serine/arginine-rich protein SF2/ASF regulates protein sumoylation.Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts.LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1Regulation and function of SUMO modification.Topoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair.Human promyelocytic leukemia protein is targeted to distinct subnuclear domains in plant nuclei and colocalizes with nucleolar constituents in a SUMO-dependent manner.Targeting Ubc9 for cancer therapy.Sumoylation and regulation of cardiac gene expression.SUMO modification of DNA topoisomerase II: trying to get a CENse of it allUbiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells.The cell's nucleolus: an emerging target for chemotherapeutic intervention.Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells.Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2.MicroRNA-mediated regulation of Ubc9 expression in cancer cells.The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.Altered phosphorylation of topoisomerase I following overexpression in an ovarian cancer cell line.Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation.Distinct effects of topoisomerase I and RNA polymerase I inhibitors suggest a dual mechanism of nucleolar/nucleoplasmic partitioning of topoisomerase I.Sumoylation of topoisomerase I is involved in its partitioning between nucleoli and nucleoplasm and its clearing from nucleoli in response to camptothecin.The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes.Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.Changes in mobility account for camptothecin-induced subnuclear relocation of topoisomerase I.Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.SUMO-1 modification alters ADAR1 editing activityAssociation of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy.SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin.SUMOylation of TOP1 with SUMO1Sumoylation and Its Contribution to Cancer.5-Flurouracil disrupts nuclear export and nuclear pore permeability in a calcium dependent manner.Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.
P2860
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P2860
Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein.
description
2001 nî lūn-bûn
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2001年の論文
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2001年学术文章
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2001年学术文章
@zh
2001年学术文章
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2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
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2001年學術文章
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name
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@en
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@nl
type
label
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@en
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@nl
prefLabel
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@en
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@nl
P2093
P2860
P356
P1476
Nucleolar delocalization of hu ...... th sumoylation of the protein.
@en
P2093
William T Beck
Yin-Yuan Mo
Zhiyuan Shen
P2860
P304
P356
10.1074/JBC.M108263200
P407
P577
2001-11-14T00:00:00Z