Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.
about
SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.Structure of a SUMO-binding-motif Mimic Bound to Smt3p–Ubc9p: Conservation of a Non-covalent Ubiquitin-like Protein–E2 Complex as a Platform for Selective Interactions within a SUMO PathwayTOR signaling is a determinant of cell survival in response to DNA damage.Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processesUbiquitin and SUMO systems in the regulation of mitotic checkpointsDistinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stressUBC9 autosumoylation negatively regulates sumoylation of septins in Saccharomyces cerevisiaeThe SUMO pathway functions in mouse oocyte maturationTopoisomerase I-dependent viability loss in saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair.Targeting Ubc9 for cancer therapy.Repair of topoisomerase I-mediated DNA damage.SUMO modification of DNA topoisomerase II: trying to get a CENse of it allUbiquitin-family modifications of topoisomerase I in camptothecin-treated human breast cancer cells.Sumoylation and the DNA damage responseThe E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint.Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy.Fission yeast Rnf4 homologs are required for DNA repair.
P2860
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P2860
Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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name
Defects in SUMO (small ubiquit ...... somerase I-induced DNA damage.
@en
Defects in SUMO
@nl
type
label
Defects in SUMO (small ubiquit ...... somerase I-induced DNA damage.
@en
Defects in SUMO
@nl
prefLabel
Defects in SUMO (small ubiquit ...... somerase I-induced DNA damage.
@en
Defects in SUMO
@nl
P2093
P2860
P356
P1476
Defects in SUMO (small ubiquit ...... isomerase I-induced DNA damage
@en
P2093
Erica S Johnson
Hervé R Jacquiau
Mary-Ann Bjornsti
Michael H Woo
Robert C A M van Waardenburg
P2860
P304
23566-23575
P356
10.1074/JBC.M500947200
P407
P577
2005-04-06T00:00:00Z