Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336.
about
Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase.Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa.Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa.Identification of plasmin-interactive sites in the light chain of factor VIII responsible for proteolytic cleavage at Lys36.Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity.Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain.Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain.Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain.Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa.
P2860
Q35819426-1414E8A4-90CA-49B4-9381-586162137724Q36873644-ABFBBE4F-CE49-4E9B-BADC-8DF286251BEEQ42533684-7E9D5E7B-1058-4631-9C59-C4F0EE85C15EQ43167061-A0DC8FFF-0788-4283-919A-9C59CA721D2AQ44727130-0294E04D-4F37-4AE9-9A8E-903D07829005Q44756930-23BA57B3-55FC-419A-A127-692598E6F063Q44912906-D6FA99E8-70DF-4518-91D7-B0A3BCC704E0Q45881688-40D78961-BEA4-401E-8E1C-1077348A8E2BQ53063691-5C9974B9-4C66-4F85-9B81-510C2E06C6BC
P2860
Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336.
description
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name
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@en
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@nl
type
label
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@en
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@nl
prefLabel
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@en
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@nl
P2093
P2860
P356
P1476
Cofactor activities of factor ...... avage of A1 subunit at Arg336.
@en
P2093
Kyla Schmidt
Maria Mastri
Mary E Koszelak Rosenblum
Philip J Fay
P2860
P304
11664-11669
P356
10.1074/JBC.M200037200
P407
P577
2002-01-17T00:00:00Z