Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells.
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Ascorbate depletion: a critical step in nickel carcinogenesis?Advances in carcinogenic metal toxicity and potential molecular markersInvolvement of free radicals in breast cancerGenetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromiumXPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromateMonitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.Influence of substrate complexity on the diastereoselective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation.Mechanism of DNA-protein cross-linking by chromiumIron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity.Mismatch repair proteins are activators of toxic responses to chromium-DNA damage.Excision repair is required for genotoxin-induced mutagenesis in mammalian cells.Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress.DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cellsGlobal molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1.Chromium in drinking water: sources, metabolism, and cancer risksWRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.The chromate-inducible chrBACF operon from the transposable element TnOtChr confers resistance to chromium(VI) and superoxide.Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolismFabrication of Unique Magnetic Bionanocomposite for Highly Efficient Removal of Hexavalent Chromium from Water.Protein expression profiling in chemical carcinogenesis: a proteomic-based approach.Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicity.Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human LungsAscorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner.Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repair.Safety and efficacy of chromium methionine (Availa® Cr) as feed additive for all speciesScientific Opinion on the risks to public health related to the presence of chromium in food and drinking water
P2860
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P2860
Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells.
description
2002 nî lūn-bûn
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2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Carcinogenic chromium(VI) indu ...... and in human lung A549 cells.
@en
type
label
Carcinogenic chromium(VI) indu ...... and in human lung A549 cells.
@en
prefLabel
Carcinogenic chromium(VI) indu ...... and in human lung A549 cells.
@en
P2093
P356
P1433
P1476
Carcinogenic chromium(VI) indu ...... and in human lung A549 cells.
@en
P2093
Anatoly Zhitkovich
George Quievryn
Joseph Messer
P304
P356
10.1021/BI011942Z
P407
P577
2002-03-01T00:00:00Z