beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
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Differentiation of insulin-producing cells from human neural progenitor cellsIdentification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survivalProtein 4.1B contributes to the organization of peripheral myelinated axonsLow-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretionDysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetesmiR-375 maintains normal pancreatic alpha- and beta-cell massInsulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeBrain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanismInsulin-like growth factor 1 has multisystem effects on foetal and preterm infant developmentBeta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intoleranceThe insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endotheliumThe forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthCoordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cellsInsulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cellsRole of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growthInsulin signaling regulates mitochondrial function in pancreatic beta-cellsIs dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceTSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasiaSequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.The negative cell cycle regulators, p27(Kip1), p18(Ink4c), and GSK-3, play critical role in maintaining quiescence of adult human pancreatic β-cells and restrict their ability to proliferate.Automated quantification of pancreatic β-cell mass.Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Experimental intrauterine growth restriction induces alterations in DNA methylation and gene expression in pancreatic islets of rats.Insulin-like growth factor 1 physiology: lessons from mouse models.Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?Abnormal glucose homeostasis and pancreatic islet function in mice with inactivation of the Fem1b gene.Effect of catch-up growth after food restriction on the entero-insular axis in rats.SH2B1 regulation of energy balance, body weight, and glucose metabolism.Tissue-specific insulin signaling in the regulation of metabolism and aging.Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreasPancreatic function in carboxyl-ester lipase knockout miceRe-expression of IGF-II is important for beta cell regeneration in adult miceGenetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.Essential role of STAT3 in body weight and glucose homeostasis.Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in miceSuccinate dehydrogenase-deficient gastrointestinal stromal tumors.Insulin resistance and pancreatic beta cell failureCre-mediated germline mosaicism: a new transgenic mouse for the selective removal of residual markers from tri-lox conditional alleles.Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
P2860
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P2860
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@en
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@nl
type
label
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@en
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@nl
prefLabel
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@en
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@nl
P2093
P356
P1433
P1476
beta-cell-specific deletion of ...... does not alter beta-cell mass.
@en
P2093
Holzenberger M
Kulkarni RN
Magnuson MA
P2888
P304
P356
10.1038/NG872
P407
P577
2002-04-01T00:00:00Z
P6179
1003838979