Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.
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Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onsetHuman GLUD2 glutamate dehydrogenase is expressed in neural and testicular supporting cellsThe discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and diseaseMultiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological ImplicationsStructure-based predictive models for allosteric hot spots.Estrogen modification of human glutamate dehydrogenases is linked to enzyme activation state.Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease.The role of glutamate dehydrogenase in mammalian ammonia metabolism.Deregulation of glutamate dehydrogenase in human neurologic disorders.The odyssey of a young gene: structure-function studies in human glutamate dehydrogenases reveal evolutionary-acquired complex allosteric regulation mechanisms.Glutamate dehydrogenase isoforms with N-terminal (His)6- or FLAG-tag retain their kinetic properties and cellular localization.The effect of pH and ADP on ammonia affinity for human glutamate dehydrogenases.Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.Purification of glutamate dehydrogenase from liver and brain.Identification of ADP-ribosylation site in human glutamate dehydrogenase isozymes.Side-chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation.Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons.
P2860
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P2860
Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Single amino acid substitution ...... rative behavior of the enzyme.
@en
Single amino acid substitution
@nl
type
label
Single amino acid substitution ...... rative behavior of the enzyme.
@en
Single amino acid substitution
@nl
prefLabel
Single amino acid substitution ...... rative behavior of the enzyme.
@en
Single amino acid substitution
@nl
P2860
P356
P1476
Single amino acid substitution ...... erative behavior of the enzyme
@en
P2093
Andreas Plaitakis
P2860
P304
26422-26428
P356
10.1074/JBC.M200022200
P407
P577
2002-04-11T00:00:00Z