Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.
about
Partial D-amino acid substitution: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptideSynthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues.Engineering endomorphin drugs: state of the art.5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists.Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: enantioselective syntheses of homoproline, pelletierine, and homopipecolic acidBifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mixed mu-agonist/delta-antagonist and dual mu-agonist/delta-agonist opioid ligands.Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue.Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs.Opioid receptor targeting ligands for pain management: a review and update.Modern tools for the chemical ligation and synthesis of modified peptides and proteins.Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2.Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides.Conformational analysis and mu-opioid receptor affinity of short peptides, endomorphin models in a low polarity solvent.Tryptophan-Containing Non-Cationizable Opioid Peptides - a new chemotype with unusual structure and in vivo activity.Probing the proteolytic stability of beta-peptides containing alpha-fluoro- and alpha-hydroxy-beta-amino acids.Three-component synthesis of polysubstituted homoproline analogs.Endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration.Expedient synthesis of pseudo-Pro-containing peptides: towards constrained peptidomimetics and foldamers
P2860
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P2860
Endomorphin-1 analogues containing beta-proline are mu-opioid receptor agonists and display enhanced enzymatic hydrolysis resistance.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@en
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@nl
type
label
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@en
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@nl
prefLabel
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@en
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@nl
P2093
P356
P1476
Endomorphin-1 analogues contai ...... zymatic hydrolysis resistance.
@en
P2093
Ahmed R Qasem
Fabio Sgarzi
Giuliana Cardillo
Luca Gentilucci
P304
P356
10.1021/JM011059Z
P407
P577
2002-06-01T00:00:00Z