The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
about
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanismsHuntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neuronspARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingMutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's diseaseCystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase.Palmitoylation of huntingtin by HIP14 is essential for its trafficking and functionPotential Roles of Adropin in Central Nervous System: Review of Current LiteratureDevelopmental Dynamics of Rett SyndromeImproving Cell Engraftment in Cardiac Stem Cell TherapyPossible involvement of self-defense mechanisms in the preferential vulnerability of the striatum in Huntington's diseaseReinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Neuroimmunology of Huntington's Disease: Revisiting Evidence from Human StudiesMotor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive ReviewPhosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairmentDopamine receptors - IUPHAR Review 13Normal huntingtin function: an alternative approach to Huntington's diseaseModulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosisA novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's diseaseThe insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7Role for Akt3/protein kinase Bgamma in attainment of normal brain sizeScalable production in human cells and biochemical characterization of full-length normal and mutant huntingtinOmi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's diseasePHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampusImpaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's diseaseSerine 421 regulates mutant huntingtin toxicity and clearance in mice.Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease.The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signalling.Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.Early energy deficit in Huntington disease: identification of a plasma biomarker traceable during disease progression.Activation of p38MAPK contributes to expanded polyglutamine-induced cytotoxicity.Neuroendocrine disturbances in Huntington's diseaseF-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristicsSerines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Oligonucleotide-based strategies to combat polyglutamine diseases.Striatal Vulnerability in Huntington's Disease: Neuroprotection Versus Neurotoxicity.Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions.
P2860
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P2860
The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@en
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@nl
type
label
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@en
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@nl
prefLabel
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@en
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@nl
P2093
P1433
P1476
The IGF-1/Akt pathway is neuro ...... ingtin phosphorylation by Akt.
@en
P2093
Elzbieta A Bryson
Frédéric Saudou
Michael E Greenberg
Nathan C Connors
Sandeep R Datta
Sandrine Humbert
Steven Finkbeiner
P304
P356
10.1016/S1534-5807(02)00188-0
P407
P577
2002-06-01T00:00:00Z