P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.
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Significance of MDR1 and multiple drug resistance in refractory human epileptic brainPathophysiological implications of neurovascular P450 in brain disordersManagement of refractory status epilepticus in adults: still more questions than answersA multi-system approach assessing the interaction of anticonvulsants with P-gpPatterns of P-glycoprotein activity in the nervous system during vincristine-induced neuropathy in ratsNanomedicine in the diagnosis and therapy of neurodegenerative disorders.Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled ratsP-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human EpilepsyDrug-Resistant Epilepsy: Multiple Hypotheses, Few AnswersDrug resistance in brain diseases and the role of drug efflux transporters.Enhanced brain delivery of lamotrigine with Pluronic(®) P123-based nanocarrierCelecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy.A proposed role for efflux transporters in the pathogenesis of hydrocephalusPhenobarbital for the treatment of epilepsy in the 21st century: a critical review.Cellular localization and functional significance of CYP3A4 in the human epileptic brain.Potential role of drug transporters in the pathogenesis of medically intractable epilepsy.An examination of the blood-brain barrier in health and disease.Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms.The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord.Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures.Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor.Antiepileptic medication during pregnancy: does fetal genotype affect outcome?Pharmacogenetics of chronic pain and its treatment.Transporter-mediated uptake into cellular compartments.The emerging importance of transporter proteins in the psychopharmacological treatment of the pregnant patient.The antiepileptic drug mephobarbital is not transported by P-glycoprotein or multidrug resistance protein 1 at the blood-brain barrier: a positron emission tomography study.One of the hottest topics in epileptology: ABC proteins. Their inhibition may be the future for patients with intractable seizures.Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains.Drug interactions at the blood-brain barrier: fact or fantasy?Prediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.Nanostructure-based drug delivery systems for brain targeting.Psychotropic drug-drug interactions involving P-glycoprotein.Pregnane X Receptor and P-glycoprotein: a connexion for Alzheimer's disease management.Intractable epilepsy and the P-glycoprotein hypothesis.Haloperidol is an inhibitor but not substrate for MDR1/P-glycoprotein.Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats.The multidrug transporter hypothesis of refractory epilepsy: corroboration and contradiction in equal measure.Antiepileptic drug transport--of mice and men.Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects.
P2860
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P2860
P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@en
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@nl
type
label
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@en
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@nl
prefLabel
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@en
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@nl
P1433
P1476
P-Glycoprotein-mediated efflux ...... odialysis experiments in rats.
@en
P2093
Maren Fedrowitz
Wolfgang Löscher
P304
P356
10.1016/S0304-3940(02)00423-8
P407
P577
2002-07-01T00:00:00Z