Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.
about
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancerThe neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAPMerlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm MaturationIntegrins in the Spotlight of CancerMerlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survivalNF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctionsBeta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelinationOncogenic role of Merlin/NF2 in glioblastoma.p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB.NF2/merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations.Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasmsContribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides.Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesisThe ErbB inhibitors trastuzumab and erlotinib inhibit growth of vestibular schwannoma xenografts in nude mice: a preliminary studySchwannomin/merlin promotes Schwann cell elongation and influences myelin segment length.Integrative data mining highlights candidate genes for monogenic myopathies.NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation.Molecular Targets and Treatment of Meningioma.The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion.Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathwaysMerlin and the ERM proteins in Schwann cells, neurons and growth cones.Role of Merlin/NF2 inactivation in tumor biology.Stability of the tumor suppressor merlin depends on its ability to bind paxillin LD3 and associate with β1 integrin and actin at the plasma membrane.Nf2/Merlin: a coordinator of receptor signalling and intercellular contactNeuregulin-1 beta and neuregulin-1 alpha differentially affect the migration and invasion of malignant peripheral nerve sheath tumor cells.Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancerThe neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent mannerDistinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activityNeuregulin and laminin stimulate phosphorylation of the NF2 tumor suppressor in Schwann cells by distinct protein kinase A and p21-activated kinase-dependent pathways.Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.Merlin regulates transmembrane receptor accumulation and signaling at the plasma membrane in primary mouse Schwann cells and in human schwannomas.
P2860
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P2860
Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Paxillin binds schwannomin and ...... and effect on cell morphology.
@en
Paxillin binds schwannomin and ...... and effect on cell morphology.
@nl
type
label
Paxillin binds schwannomin and ...... and effect on cell morphology.
@en
Paxillin binds schwannomin and ...... and effect on cell morphology.
@nl
prefLabel
Paxillin binds schwannomin and ...... and effect on cell morphology.
@en
Paxillin binds schwannomin and ...... and effect on cell morphology.
@nl
P2093
P356
P1433
P1476
Paxillin binds schwannomin and ...... and effect on cell morphology.
@en
P2093
Alma Rodenas-Ruano
Cristina Fernandez-Valle
Elizabeth Hackler
Jared Iacovelli
John Biggerstaff
P2888
P304
P356
10.1038/NG930
P407
P577
2002-07-15T00:00:00Z