Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes.
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A novel adaptation of the integrin PSI domain revealed from its crystal structureProtein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrinsPlatelet protein disulfide isomerase is required for thrombus formation but not for hemostasis in micePathogenic hantaviruses bind plexin-semaphorin-integrin domains present at the apex of inactive, bent alphavbeta3 integrin conformersProtein disulfide isomerase in thrombosis and vascular inflammationThe platelet-surface thiol isomerase enzyme ERp57 modulates platelet function.Glanzmann's thrombasthenia: an overview.Identification of integrin beta subunit mutations that alter affinity for extracellular matrix ligand.Possibilities for tailored and targeted therapy in paediatric acute myeloid leukaemia.Lung extracellular matrix and redox regulationIdentification of integrin beta subunit mutations that alter heterodimer function in situ.Immunoregulation through membrane proteins modified by reducing conditions induced by immune reactions.Redox-relevant aspects of the extracellular matrix and its cellular contacts via integrinsLow affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection.Redox regulation of the actin cytoskeleton and its role in the vascular system.Proteinase inhibition by proform of eosinophil major basic protein (pro-MBP) is a multistep process of intra- and intermolecular disulfide rearrangements.Critical cysteine residues for regulation of integrin alphaIIbbeta3 are clustered in the epidermal growth factor domains of the beta3 subunit.Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension.Detection of integrin alpha IIbbeta 3 clustering in living cells.Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation.Factor H binds to platelet integrin alphaIIbbeta3.The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy.Amino acid changes in Drosophila alphaPS2betaPS integrins that affect ligand affinity.Ultraviolet C light pathogen inactivation treatment of platelet concentrates preserves integrin activation but affects thrombus formation kinetics on collagen in vitro.Reduction of leucocyte cell surface disulfide bonds during immune activation is dynamic as revealed by a quantitative proteomics workflow (SH-IQ)
P2860
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P2860
Disruption of the long-range GPIIIa Cys(5)-Cys(435) disulfide bond results in the production of constitutively active GPIIb-IIIa (alpha(IIb)beta(3)) integrin complexes.
description
2002 nî lūn-bûn
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2002年の論文
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年学术文章
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2002年學術文章
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name
Disruption of the long-range GPIIIa Cys
@nl
Disruption of the long-range G ...... b)beta(3)) integrin complexes.
@en
type
label
Disruption of the long-range GPIIIa Cys
@nl
Disruption of the long-range G ...... b)beta(3)) integrin complexes.
@en
prefLabel
Disruption of the long-range GPIIIa Cys
@nl
Disruption of the long-range G ...... b)beta(3)) integrin complexes.
@en
P2093
P1433
P1476
Disruption of the long-range G ...... b)beta(3)) integrin complexes.
@en
P2093
Cathy Paddock
Chao-Yan Liu
Peter J Newman
Qi-Hong Sun
Ronggang Wang
P304
P356
10.1182/BLOOD-2002-02-0418
P407
P577
2002-09-01T00:00:00Z