Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development.
about
Diversity and repertoire of IgW and IgM VH families in the newborn nurse sharkFish ImmunoglobulinsRNA mutagenesis yields highly diverse mRNA libraries for in vitro protein evolution.Isolation of anti-toxin single domain antibodies from a semi-synthetic spiny dogfish shark display library.Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points.First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate.The immunoglobulins of cold-blooded vertebratesThe multiple shark Ig H chain genes rearrange and hypermutate autonomously.The Shark Strikes Twice: Hypervariable Loop 2 of Shark IgNAR Antibody Variable Domains and Its Potential to Function as an Autonomous Paratope.Origin of immunoglobulin isotype switching.The plasticity of immunoglobulin gene systems in evolution.Conservation and diversity in the ultralong third heavy-chain complementarity-determining region of bovine antibodiesStructural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.Nanobody; an old concept and new vehicle for immunotargeting.Immunoglobulin domains in Escherichia coli and other enterobacteria: from pathogenesis to applications in antibody technologies.What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy.Shark variable new antigen receptor biologics - a novel technology platform for therapeutic drug development.Structural insights and biomedical potential of IgNAR scaffolds from sharks.Single-domain antibodies for biomedical applications.Analysis of the binding loops configuration and surface adaptation of different crystallized single-domain antibodies in response to various antigens.Structure of a shark IgNAR antibody variable domain and modeling of an early-developmental isotype.Single Domain Antibodies as New Biomarker Detectors.Generation of Semi-Synthetic Shark IgNAR Single-Domain Antibody Libraries.Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus.Diversity in the Cow Ultralong CDR H3 Antibody Repertoire.
P2860
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P2860
Structural analysis, selection, and ontogeny of the shark new antigen receptor (IgNAR): identification of a new locus preferentially expressed in early development.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Structural analysis, selection ...... xpressed in early development.
@en
Structural analysis, selection ...... xpressed in early development.
@nl
type
label
Structural analysis, selection ...... xpressed in early development.
@en
Structural analysis, selection ...... xpressed in early development.
@nl
prefLabel
Structural analysis, selection ...... xpressed in early development.
@en
Structural analysis, selection ...... xpressed in early development.
@nl
P2093
P1433
P1476
Structural analysis, selection ...... xpressed in early development.
@en
P2093
Andrew S Greenberg
Marilyn Diaz
Robyn L Stanfield
P2888
P304
P356
10.1007/S00251-002-0479-Z
P407
P577
2002-07-23T00:00:00Z