Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy. - Wikidata - awgldk - TriplyDB

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

http://www.wikidata.org/entity/Q44195721

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Limitations of allotopic expression of mitochondrial genes in mammalian cells Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?Mitochondrial DNA mutations in human disease Genetic manipulation for inherited neurodegenerative diseases: myth or reality?Leber hereditary optic neuropathy: current perspectives A neurodegenerative perspective on mitochondrial optic neuropathies Is there treatment for Leber hereditary optic neuropathy?Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.Diagnosis and management of MELAS.Treatment strategies for inherited optic neuropathies: past, present and future Mitochondrial DNA analysis in primary congenital glaucoma Identification of novel mitochondrial mutations in Leber's hereditary optic neuropathy Medical management of hereditary optic neuropathies.Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential loss The optic nerve: a "mito-window" on mitochondrial neurodegeneration The neuro-ophthalmology of mitochondrial disease Gene therapy for the treatment of mitochondrial DNA disorders.Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.Cell and animal models of mtDNA biology: progress and prospects.LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein.Mitochondrial DNA: impacting central and peripheral nervous systems.Leber's Hereditary Optic Neuropathy: The Mitochondrial Connection Revisited Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system LHON: Mitochondrial Mutations and More.Cell response to oxidative stress induced apoptosis in patients with Leber's hereditary optic neuropathy.Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.Mitochondrial energetics and therapeutics.Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Gene therapy for optic nerve disease.Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice Induction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.Clinical characterization and mitochondrial DNA sequence variations in Leber hereditary optic neuropathy.Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy.Mitochondrial DNA nucleotide changes in primary congenital glaucoma patients Gene therapy of the other genome: the challenges of treating mitochondrial DNA defects.

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Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

http://www.wikidata.org/entity/Q44195721

description

2002 nî lūn-bûn

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年學術文章

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2002年學術文章

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name

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@en

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@nl

type

label

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@en

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@nl

prefLabel

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@en

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@nl

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P1433

Annals of Neurology

P1476

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.

@en

P2093

Eric A Schon

http://www.w3.org/2001/XMLSchema#string

Francesco Pallotti

http://www.w3.org/2001/XMLSchema#string

Giovanni Manfredi

http://www.w3.org/2001/XMLSchema#string

John Guy

http://www.w3.org/2001/XMLSchema#string

Valerio Carelli

http://www.w3.org/2001/XMLSchema#string

William W Hauswirth

http://www.w3.org/2001/XMLSchema#string

Xiaoping Qi

http://www.w3.org/2001/XMLSchema#string

P2860

Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON)

Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy

Mitochondrial diseases in man and mouse

Mitochondrial genetics and disease.

Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.

Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.

Optic nerve degeneration and mitochondrial dysfunction: genetic and acquired optic neuropathies.

Mitochondrial disease in mouse results in increased oxidative stress.

Adeno-associated viral-mediated catalase expression suppresses optic neuritis in experimental allergic encephalomyelitis.

Compensatory elevation of complex II activity in Leber's hereditary optic neuropathy.

P304

534-542

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scholarly article

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10.1002/ANA.10354

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5

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52

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Andrea Martinuzzi

Alfred S. Lewin

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2002-11-01T00:00:00Z

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P698

12402249

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