Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
about
Limitations of allotopic expression of mitochondrial genes in mammalian cellsAllotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?Mitochondrial DNA mutations in human diseaseGenetic manipulation for inherited neurodegenerative diseases: myth or reality?Leber hereditary optic neuropathy: current perspectivesA neurodegenerative perspective on mitochondrial optic neuropathiesIs there treatment for Leber hereditary optic neuropathy?Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.Diagnosis and management of MELAS.Treatment strategies for inherited optic neuropathies: past, present and futureMitochondrial DNA analysis in primary congenital glaucomaIdentification of novel mitochondrial mutations in Leber's hereditary optic neuropathyMedical management of hereditary optic neuropathies.Mitochondrial complex II prevents hypoxic but not calcium- and proapoptotic Bcl-2 protein-induced mitochondrial membrane potential lossThe optic nerve: a "mito-window" on mitochondrial neurodegenerationThe neuro-ophthalmology of mitochondrial diseaseGene therapy for the treatment of mitochondrial DNA disorders.Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.Cell and animal models of mtDNA biology: progress and prospects.LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.mRNA localization to the mitochondrial surface allows the efficient translocation inside the organelle of a nuclear recoded ATP6 protein.Mitochondrial DNA: impacting central and peripheral nervous systems.Leber's Hereditary Optic Neuropathy: The Mitochondrial Connection RevisitedEfficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual systemLHON: Mitochondrial Mutations and More.Cell response to oxidative stress induced apoptosis in patients with Leber's hereditary optic neuropathy.Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.Mitochondrial energetics and therapeutics.Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.Mitochondrial Diseases Part III: Therapeutic interventions in mouse models of OXPHOS deficiencies.Gene therapy for optic nerve disease.Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in miceInduction of rapid and highly efficient expression of the human ND4 complex I subunit in the mouse visual system by self-complementary adeno-associated virus.Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.Clinical characterization and mitochondrial DNA sequence variations in Leber hereditary optic neuropathy.Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy.Mitochondrial DNA nucleotide changes in primary congenital glaucoma patientsGene therapy of the other genome: the challenges of treating mitochondrial DNA defects.
P2860
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P2860
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@en
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@nl
type
label
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@en
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@nl
prefLabel
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@en
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@nl
P2093
P2860
P356
P1433
P1476
Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy.
@en
P2093
Eric A Schon
Francesco Pallotti
Giovanni Manfredi
Valerio Carelli
William W Hauswirth
Xiaoping Qi
P2860
P304
P356
10.1002/ANA.10354
P577
2002-11-01T00:00:00Z