Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering. - Wikidata - awgldk - TriplyDB

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.

http://www.wikidata.org/entity/Q44240662

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Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity Structural basis for angiopoietin-1-mediated signaling initiation.Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4 Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice Angiopoietin 2 mediates the differentiation and migration of neural progenitor cells in the subventricular zone after stroke.Angiopoietin 2 signaling plays a critical role in neural crest cell migration.Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy Angiopoietin-2: development of inhibitors for cancer therapy.Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway Angiopoietins, abdominal aortic aneurysm and atherosclerosis.Molecular control of angiopoietin signalling.Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation.Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade The angiopoietin-Tie2 signaling axis in the vascular leakage of systemic inflammation Intra and extravascular transmembrane signalling of angiopoietin-1-Tie2 receptor in health and disease.Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2.Inhibition of endothelial/smooth muscle cell contact loss by the investigational angiopoietin-2 antibody MEDI3617.A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization.Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner.The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway.Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus The dynamic roles of angiopoietins in tumor angiogenesis.Signaling and functions of angiopoietin-1 in vascular protection.Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation The opening act: vasculogenesis and the origins of circulation.Angiopoietin-2 attenuates angiotensin II-induced aortic aneurysm and atherosclerosis in apolipoprotein E-deficient mice.Aflibercept and Ang1 supplementation improve neoadjuvant or adjuvant chemotherapy in a preclinical model of resectable breast cancer.Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2.Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis.Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?Mast cell-derived angiopoietin-1 plays a critical role in the growth of plasma cell tumors.

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P2860

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.

http://www.wikidata.org/entity/Q44240662

description

2003 nî lūn-bûn

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2003年の論文

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Angiopoietins have distinct mo ...... erization and superclustering.

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Angiopoietins have distinct mo ...... erization and superclustering.

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Angiopoietins have distinct mo ...... erization and superclustering.

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Angiopoietins have distinct mo ...... erization and superclustering.

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Angiopoietins have distinct mo ...... erization and superclustering.

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Angiopoietins have distinct mo ...... erization and superclustering.

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Nature structural biology

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Angiopoietins have distinct mo ...... erization and superclustering.

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P2093

April Xu

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Ashique Rafique

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Czeslaw Radziejewski

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Ella Ioffe

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Elzbieta Radziejewska

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George D Yancopoulos

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Jim Fandl

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John S Rudge

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Judah Goldberg

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Kevin Bailey

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38-44

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scholarly article

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10.1038/NSB880

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1

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10

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11002771

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12469114

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