Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents. - Wikidata - awgldk - TriplyDB

Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.

Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.

http://www.wikidata.org/entity/Q44259205

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Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis Is There Room for Second-Generation Antipsychotics in the Pharmacotherapy of Panic Disorder? A Systematic Review Based on PRISMA Guidelines Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia Inhibition of evoked glutamate release by neurosteroid allopregnanolone via inhibition of L-type calcium channels in rat medial prefrontal cortex Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics GABA receptor subunit distribution and FMRP-mGluR5 signaling abnormalities in the cerebellum of subjects with schizophrenia, mood disorders, and autism.Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection Expression of GABAA α2-, β1- and ε-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder Evidence for a role of progesterone in menstrual cycle-related variability in prepulse inhibition in healthy young women.Anxiolytic-like property of risperidone and olanzapine as examined in multiple measures of fear in rats.GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders.Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia.Simultaneous quantification of GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in human and rat serum.Differential effects of ethanol on serum GABAergic 3alpha,5alpha/3alpha,5beta neuroactive steroids in mice, rats, cynomolgus monkeys, and humans.Ethanol induction of steroidogenesis in rat adrenal and brain is dependent upon pituitary ACTH release and de novo adrenal StAR synthesis Time-lapse mapping of cortical changes in schizophrenia with different treatments Hypothalamic-pituitary-adrenal axis modulation of GABAergic neuroactive steroids influences ethanol sensitivity and drinking behavior Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.Effects and Mechanisms of 3α,5α,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor.Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation.Progesterone attenuates depressive behavior of younger and older adult C57/BL6, wildtype, and progesterone receptor knockout mice.Neuroactive steroids in schizophrenia.Hippocampal shape and volume changes with antipsychotics in early stage psychotic illness.Olanzapine: a 5-year perspective.Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.Progesterone reduces depressive behavior of young ovariectomized, aged progestin receptor knockout, and aged wild type mice in the tail suspension test.A preclinical and clinical rationale for quetiapine in mood syndromes.Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: contrast with haloperidol and chlordiazepoxide.Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?Catatonia Secondary to Sudden Clozapine Withdrawal: A Case with Three Repeated Episodes and a Literature Review.Progesterone and its metabolites as therapeutic targets in psychiatric disorders.Current Neurogenic and Neuroprotective Strategies to Prevent and Treat Neurodegenerative and Neuropsychiatric Disorders.GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells.Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential.Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents.Cortisol/dehydroepiandrosterone ratio and responses to antipsychotic treatment in schizophrenia.Chronic treatment with serotonin reuptake inhibitor antidepressant (SSRI) combined with an antipsychotic regulates GABA-A receptor in rat prefrontal cortex.Access to the CNS: Biomarker Strategies for Dopaminergic Treatments.

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Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.

http://www.wikidata.org/entity/Q44259205

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Olanzapine and clozapine incre ...... d allopregnanolone in rodents.

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Olanzapine and clozapine incre ...... d allopregnanolone in rodents.

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Olanzapine and clozapine incre ...... d allopregnanolone in rodents.

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Neuropsychopharmacology

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Olanzapine and clozapine incre ...... d allopregnanolone in rodents.

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A Leslie Morrow

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Christine E Marx

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Gary E Duncan

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Jeffrey A Lieberman

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Margaret J VanDoren

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P2860

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

Increased baseline occupancy of D2 receptors by dopamine in schizophrenia

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination

Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects

The blunted plasma cortisol response to apomorphine and its relationship to treatment response in patients with schizophrenia.

Progesterone as a neurosteroid: synthesis and actions in rat glial cells.

Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia.

GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder.

Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.

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10.1038/SJ.NPP.1300015

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