Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.
about
Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922Exploring the Functional Complementation between Grp94 and Hsp90Hsp-90 and the biology of nematodes.Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.Functional genomics of hsp-90 in parasitic and free-living nematodes.TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast.Nematode Hsp90: highly conserved but functionally diverse.An acetylation site in the middle domain of Hsp90 regulates chaperone function.In the yeast heat shock response, Hsf1-directed induction of Hsp90 facilitates the activation of the Slt2 (Mpk1) mitogen-activated protein kinase required for cell integrity.Fungal heat-shock proteins in human disease.p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activityHsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37.Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious diseaseMolecular chaperones in pathogen virulence: emerging new targets for therapy.Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges.Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53.
P2860
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P2860
Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@en
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@nl
type
label
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@en
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@nl
prefLabel
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@en
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@nl
P2093
P1433
P1476
Yeast is selectively hypersens ...... ew Hsp90 chaperone inhibitors.
@en
P2093
Andrew Truman
Barry Panaretou
Laurence H Pearl
Mehdi Mollapour
Peter W Piper
Stefan H Millson
P304
P356
10.1016/S0378-1119(02)01102-2
P407
P577
2003-01-01T00:00:00Z