Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.
about
Crystal structure of human cytochrome P450 2C9 with bound warfarinStructural features of cytochromes P450 and ligands that affect drug metabolism as revealed by X-ray crystallography and NMR.Modeling kinetic data from in vitro drug metabolism enzyme experiments.Predicting in vivo drug interactions from in vitro drug discovery data.Inhibition of recombinant cytochrome P450 isoforms 2D6 and 2C9 by diverse drug-like moleculesThe structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.Improving the activity of cytochrome P450 BM-3 catalyzing indole hydroxylation by directed evolution.Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin"Allosterism" in the elementary steps of the cytochrome P450 reaction cycle.Inhibition of CYP2B4 by 2-ethynylnaphthalene: evidence for the co-binding of substrate and inhibitor within the active site.Current views on the fundamental mechanisms of cytochrome P450 allosterism.Enzyme source effects on CYP2C9 kinetics and inhibitionSubstrate binding to cytochromes P450.Cooperative properties of cytochromes P450.New cytochrome P450 mechanisms: implications for understanding molecular basis for drug toxicity at the level of the cytochrome.Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme 'active site' pocket plays a relatively 'passive role' in some enzyme-substrate interactionsSubstrate proton to heme distances in CYP2C9 allelic variants and alterations by the heterotropic activator, dapsone.Resolution of multiple substrate binding sites in cytochrome P450 3A4: the stoichiometry of the enzyme-substrate complexes probed by FRET and Job's titration.Substrate Dependent Native Luminescence from Cytochromes P450 3A4, 2C9, and P450cam.Mechanism-based inactivation of cytochrome P450 2C9 by tienilic acid and (+/-)-suprofen: a comparison of kinetics and probe substrate selection.Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomes.Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.Influence of fluorescent probe size and cytochrome b5 on drug-drug interactions in CYP2C9.
P2860
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P2860
Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Activation of cytochrome P450 ...... pport of kinetic observations.
@en
Activation of cytochrome P450 ...... pport of kinetic observations.
@nl
type
label
Activation of cytochrome P450 ...... pport of kinetic observations.
@en
Activation of cytochrome P450 ...... pport of kinetic observations.
@nl
prefLabel
Activation of cytochrome P450 ...... pport of kinetic observations.
@en
Activation of cytochrome P450 ...... pport of kinetic observations.
@nl
P2093
P1476
Activation of cytochrome P450 ...... pport of kinetic observations.
@en
P2093
J Matthew Hutzler
Jan L Wahlstrom
Larry C Wienkers
Timothy J Carlson
Timothy S Tracy
P356
10.1016/S0003-9861(02)00665-3
P407
P577
2003-02-01T00:00:00Z